Authors: Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ PMID: 32192578 PMCID: PMC7270045 DOI: 10.1016/S0140-6736(20)30628-0 Abstract As of March 12, 2020, coronavirus disease 2019 (COVID-19) has been confirmed in 125 048 people worldwide, carrying a mortality of approximately 3·7%,1 compared with a mortality rate of less than 1% from influenza. There [...]

Authors: Zhou Y, Fu B, Zheng X, Wang D, Zhao C PMID: 34676125 PMCID: PMC7108005 DOI: 10.1093/nsr/nwaa041 Abstract Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity and mortality [1,2]. Recently, a severe pneumonia-associated respiratory syndrome caused by a new coronavirus (SARS-CoV-2) [...]

Authors: Wu D, Yang XO PMID: 32205092 PMCID: PMC7156211 DOI: 10.1016/j.jmii.2020.03.005 Abstract COVID-19 emerges as a pandemic disease with high mortality. Development of effective prevention and treatment is an urgent need. We reviewed TH17 responses in patients with SARS-CoV-2 and proposed an FDA approved JAK2 inhibitor Fedratinib for reducing mortality of patients with TH17 type [...]

Authors: Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z PMID: 32171076 PMCID: PMC7270627 DOI: 10.1016/S0140-6736(20)30566-3 Abstract Background: Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients [...]

Authors: Li K, Wu J, Wu F, Guo D, Cen L, Fang Z et al. PMID: 32118615 PMCID: PMC7147273 DOI: 10.1097/RLI.0000000000000672 Abstract Objective: The aim of this study was to investigate the clinical and computed tomography (CT) features associated with severe and critical coronavirus disease 2019 (COVID-19) pneumonia. Materials and methods: Eighty-three patients with COVID-19 [...]

Authors: Kanne JP, Little BP, Chung JH, Elicker BM PMID: 32105562 PMCID: PMC7233379 DOI: 10.1148/radiol.2020200527 Abstract Infections by COVID-19 continue to increase in China and worldwide. The betacoronavirus was first reported in December 2019 in Wuhan, China. As of February 24, 2020, the World Health Organization (WHO) reports 78,811 laboratory-confirmed cases, including more than 2200 [...]

Authors: Pan F, Ye T, Sun P, Gui S, Liang B, Li L PMID: 32053470 PMCID: PMC7233367 DOI: 10.1148/radiol.2020200370 Abstract Background Chest CT is used to assess the severity of lung involvement in coronavirus disease 2019 (COVID-19). Purpose To determine the changes in chest CT findings associated with COVID-19 from initial diagnosis until patient recovery. [...]

Authors: Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y et al. PMID: 31986264 PMCID: PMC7159299 DOI: 10.1016/S0140-6736(20)30183-5 Abstract Background: A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and [...]

Auhtors: Bhardwaj K, Liu P, Leibowitz JL, Kao CC PMID: 22301153 PMCID: PMC3318636 DOI: 10.1128/JVI.07012-11 Abstract Coronaviruses encode an endoribonuclease, Nsp15, which has a poorly defined role in infection. Sequence analysis revealed a retinoblastoma protein-binding motif (LXCXE/D) in the majority of the Nsp15 of the severe acute respiratory syndrome coronavirus (SARS-CoV) and its orthologs in [...]

Authors: Pan H, Peto R, Karim QA, Alejandria M, Henao-Restrepo AM PMID: 33264556 PMCID: PMC7727327 DOI: 10.1056/NEJMoa2023184 Abstract Background: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 (Covid-19). Methods: We randomly assigned inpatients with Covid-19 [...]