Authors: Isidori AM, Giannetta E, Pofi R, Venneri MA, Gianfrilli D, Campolo F PMID: 32526061 PMCID: PMC7307129 DOI: 10.1111/andr.12837 Abstract Background: A pandemic outbreak of COVID-19 has been sweeping the world since December. It begins as a respiratory infection that, mainly in men with diabetes or renal impairment, evolves into a systemic disease, with SARDS, [...]

Authors: Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S PMID: 32167524 PMCID: PMC7070509 DOI: 10.1001/jamainternmed.2020.0994 Abstract Importance: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been [...]

Authors: von der Thusen J, van der Eerden M PMID: 32353898 PMCID: PMC7267318 DOI: 10.1111/eci.13259 Abstract Background: The clinical features of COVID-19 pneumonia range from a mild illness to patients with a very severe illness with acute hypoxemic respiratory failure requiring ventilation and Intensive Care Unit admission. Aims: To provide a brief overview of the [...]

Authors: Mario L, Roberto M, Marta L, Teresa CM, Laura M PMID: 32939238 PMCID: PMC7478270 doi: 10.4103/ijpvm.IJPVM_258_20 Abstract Backgound: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible [...]

Authors: Brosnahan SB, Bhatt A, Berger JS, Yuriditsky E, Iturrate E PMID: 32589950 PMCID: PMC7309731 DOI: 10.1016/j.chest.2020.06.023 Abstract VTE is an important, dangerous, and sometimes fatal complication of coronavirus disease 2019 (COVID-19). Thrombosis, including ischemic heart disease and stroke, contributes to the overall disease burden in all non-COVID patient populations worldwide, accounting for approximately one [...]

Authors: Khamis F, Al-Zakwani I, Al Hashmi S, Al Dowaiki S, Al Bahrani M PMID: 32585284 PMCID: PMC7308750 DOI: 10.1016/j.ijid.2020.06.064 Abstract Objective: To evaluate the therapeutic use of plasma exchange in COVID-19 patients compared to controls. Methods: A case series of critically ill adult men and non-pregnant women, ≥18 years of age, with laboratory-confirmed COVID-19, [...]

Authors: Schultze A, Walker AJ, MacKenna B, Morten CE, Bhaskaran K, Brown JP doi: https://doi.org/10.1101/2020.06.19.20135491 Abstract Background Early descriptions of the coronavirus outbreak showed a lower prevalence of asthma and COPD than was expected for people diagnosed with COVID-19, leading to speculation that inhaled corticosteroids (ICS) may protect against infection with SARS-CoV-2, and development of [...]

Authors: Parry AH, Wani AH, Shah NN, Yaseen M, Jehangir M PMID: 33178976 PMCID: PMC7594891 DOI: 10.1259/bjro.20200016 Abstract Objective: To study the spectrum of chest CT features in coronavirus disease-19 (COVID-19) pneumonia and to identify the initial CT findings that may have the potential to predict a poor short-term outcome. Methods: This was a retrospective [...]

Authors: Li S, Jiang L, Li X, Lin F, Wang Y, Li B PMID: 32427582 PMCID: PMC7406259 DOI: 10.1172/jci.insight.138070 Abstract Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), has become a pandemic. This study addresses the clinical and immunopathological characteristics of severe COVID-19. Methods: Sixty-nine patients with COVID-19 were classified [...]

Authors: Seifirad S PMID: 32575019 PMCID: PMC7297676 DOI: 10.1016/j.mehy.2020.110005 Abstract Cytokine storm, multiorgan failure, and particularly acute respiratory distress syndrome (ARDS) is the leading cause of mortality and morbidity in patients with COVID-19. A fulminant ARDS kills the majority of COVID-19 victims. Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel anti-fibrotic agent with trivial adverse effects. Pirfenidone is [...]