Auhtors: Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin JP, et al. PMID: 32534647 PMCID: PMC7294238 DOI: 10.1016/S0140-6736(20)30366-4 Abstract Background: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 [...]

Auhtors: Agrawal S, Wozniak M, Luc M, Makuch S, Pielka E, Agrawal AK, et al. PMID: 31719636 PMCID: PMC6851401 DOI: 10.1038/s41598-019-53145-x Abstract The present state of cancer chemotherapy is unsatisfactory. New anticancer drugs that marginally improve the survival of patients continue to be developed at an unsustainably high cost. The study aimed to elucidate the [...]

Auhtors: Huang W, Sundquist J, Sundquist K, Ji J PMID: 31103628 DOI: 10.1053/j.gastro.2019.05.012 Abstract Background & aims: Phosphodiesterase 5 (PDE5) inhibitors have been proposed to have chemopreventative effects on colorectal cancer (CRC), although data are needed from population-based studies. We performed a nationwide cohort study to investigate the association between the use of PDE5 inhibitors [...]

Auhtors: Chandrasekaran B, Pal D, Kolluru V, Tyagi A, Baby B, Dahiya NR, et al. PMID: 30124785 PMCID: PMC6314334 DOI: 10.1093/carcin/bgy109 Abstract Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal and colon carcinogenesis remain unknown. We investigated the chemopreventive effect of WA on transgenic adenomatous polyposis coli (APCMin/+) mouse and chemically induced [...]

Auhtors: Sun P, Wang H, He Z, Chen X, Wu Q, Chen W, et al. PMID: 29088814 PMCID: PMC5650369 DOI: 10.18632/oncotarget.20301 Abstract Dietary restriction has been recognized as a healthy and natural therapy for cancer. It is reported that different forms of dietary restriction can promote anti-tumor immunity. However, it is not clear how fasting [...]

Auhtors: Medema JP PMID: 28854096 DOI: 10.1056/NEJMcibr1706541 Abstract Two recent studies in mice show that, on ablation of colon cancer stem cells, differentiated cancer cells can dedifferentiate to supply a new pool of cancer stem cells, and extracellular signals have a role in this process. Keywords: colorectal cancer, stem cell Source: https://pubmed.ncbi.nlm.nih.gov/28854096/ Archive: https://archive.is/UgkLh [...]

Auhtors: Williamson T, Bai RY, Staedtke V, Huso D, Riggins GJ PMID: 27612418 PMCID: PMC5356574 DOI: 10.18632/oncotarget.11851 Abstract Inheritance of a gene mutation leads to the initiation of 5 to 10% of most cancers, including colon cancer cases. We developed a chemoprevention strategy using a novel combination of the non-steroidal anti-inflammatory (NSAID) sulindac plus the [...]

Auhtors: Mei XL, Yang Y, Zhang YJ, Li Y, Zhao JM, Qiu JG, et al. PMID: 26807313 PMCID: PMC4697679 Abstract Colorectal cancer is the third most common human cancer with frequent overexpression of the cGMP-specific phosphodiesterase 5 (PDE5). In the present study, we investigated that the anticancer effect of sildenafil on human colorectal cancer in [...]

Auhtors: Ng K, Venook AP, Sato K, Yuan C, Hollis BW, Chang IW, et al. doi: https://doi.org/10.1200/jco.2015.33.15_suppl.3503 Abstract Background: Prospective epidemiologic data suggest that higher levels of 25-hydroxyvitamin D [25(OH)D] are associated with improved survival in patients with colorectal cancer, however the relationship between 25(OH)D and outcome in metastatic CRC (mCRC), specifically, is unknown. Methods: [...]

Auhtors: Meyerhardt JA, Sato K, Niedzwiecki D, Ye C, Saltz LB, Mayer RJ, et al. PMID: 23136358 PMCID: PMC3502194 DOI: 10.1093/jnci/djs399 Abstract Background: The influence of glycemic load and related measures on survival among colon cancer patients remains largely unknown. Methods: We conducted a prospective, observational study of 1011 stage III colon cancer patients reporting [...]