Auhtors: Morgan G, Ward R, Barton M PMID: 15630849 DOI: 10.1016/j.clon.2004.06.007 Abstract Aims: The debate on the funding and availability of cytotoxic drugs raises questions about the contribution of curative or adjuvant cytotoxic chemotherapy to survival in adult cancer patients. Materials and methods: We undertook a literature search for randomised clinical trials reporting a 5-year [...]

Auhtors: Ayre SG, Bellon DP, Garcia DP, Jr. PMID: 11000062 DOI: 10.1054/mehy.2000.1063 Abstract The endogenous molecular biology of cancer cells involves autocrine and paracrine secretion of insulin and insulin-like growth-factors I and II, which subserve energy production and growth stimulation, respectively, in these cells. These activities confer on cancer its malignant potential, working as they [...]