Auhtors: Ambrosone CB, Zirpoli GR, Hutson AD, McCann WE, McCann SE, Barlow WE, et al. PMID: 31855498 PMCID: PMC7062457 DOI: 10.1200/JCO.19.01203 Abstract Purpose: Despite reported widespread use of dietary supplements during cancer treatment, few empirical data with regard to their safety or efficacy exist. Because of concerns that some supplements, particularly antioxidants, could reduce the [...]

Auhtors: An KY, Morielli AR, Kang DW, Friedenreich CM, McKenzie DC, Gelmon K, et al. PMID: 31173341 DOI: 10.1002/ijc.32493 Abstract The Combined Aerobic and Resistance Exercise (CARE) Trial compared different types and doses of exercise performed during breast cancer chemotherapy. Here, we report the longer-term follow-up of patient-reported outcomes, health-related fitness and exercise behavior at [...]

Auhtors: Savage P PMID: 25605631 PMCID: PMC4308945 DOI: 10.1186/s12885-015-1006-6 Abstract Background: A select number of relatively rare metastatic malignancies comprising trophoblast tumours, the rare childhood cancers, germ cells tumours, leukemias and lymphomas have been routinely curable with chemotherapy for more than 30 years. However for the more common metastatic malignancies chemotherapy treatment frequently brings clinical [...]

Auhtors: Bourdel-Marchasson I, Blanc-Bisson C, Doussau A, Germain C, Blanc JF, Dauba J, et al. PMID: 25265392 PMCID: PMC4181649 DOI: 10.1371/journal.pone.0108687 Abstract Objective: We tested the effect of dietary advice dedicated to increase intake in older patients at risk for malnutrition during chemotherapy, versus usual care, on one-year mortality. Method: We conducted a multicentre, open-label [...]

Authors: Hine C, Mitchell JR PMID: 24905161 PMCID: PMC4278638 DOI: 10.1016/j.stem.2014.05.016 Abstract Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic [...]

Authors: Nowotarski SL, Woster PM, Casero RA PMID: 23432971 PMCID: PMC4027058 DOI: 10.1017/erm.2013.3 Abstract Polyamines are small organic cations that are essential for normal cell growth and development in eukaryotes. Under normal physiological conditions, intracellular polyamine concentrations are tightly regulated through a dynamic network of biosynthetic and catabolic enzymes, and a poorly characterised transport system. [...]

Auhtors: Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI PMID: 23142798 DOI: 10.1177/1534735412464551 Abstract Hypothesis. Withania somnifera is an herb with antioxidant, anti-inflammatory, anticancer, antistress, and adaptogenic properties. Previous studies have shown its antistress effects in animals. Traditional Indian medicine has used it for centuries to alleviate fatigue and improve general well-being. Methods: [...]

Auhtors: Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Pistoria V, Wei M. PMID: 22323820 PMCID: PMC3608686 DOI: 10.1126/scitranslmed.3003293 Abstract Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. Here, we show that treatment with starvation conditions sensitized yeast cells [...]

Auhtors: Baldwin C, Spiro A, McGough C, Norman AR, Gillbanks A, Thomas K, et al. PMID: 21733143 DOI: 10.1111/j.1365-277X.2011.01189.x Abstract Background: Weight loss in patients with cancer is common and associated with a poorer survival and quality of life. Benefits from nutritional interventions are unclear. The present study assessed the effect of dietary advice and/or [...]

Auhtors: Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB PMID: 18505970 DOI: 10.1093/jnci/djn148 Abstract Despite nearly two decades of research investigating the use of dietary antioxidant supplementation during conventional chemotherapy and radiation therapy, controversy remains about the efficacy and safety of this complementary treatment. Several randomized clinical trials have demonstrated that [...]