Auhtors: Meidenbauer JJ, Mukherjee P, Seyfried TN Abstract Background Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain [...]

Auhtors: Seyfried TN, Kiebish MA, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P PMID: 20804725 DOI: 10.1016/j.bbabio.2010.08.009 Abstract Malignant brain tumors are a significant health problem in children and adults. Conventional therapeutic approaches have been largely unsuccessful in providing long-term management. As primarily a metabolic disease, malignant brain cancer can be managed through changes in [...]

Auhtors: Zhou W, Mukherjee P, Kiebish MA, Markis WT, Mantis JG, Seyfried TN PMID: 17313687 PMCID: PMC1819381 DOI: 10.1186/1743-7075-4-5 Abstract Background: Malignant brain cancer persists as a major disease of morbidity and mortality in adults and is the second leading cause of cancer death in children. Many current therapies for malignant brain tumors fail to [...]