Authors: Chiumello D, Cressoni M, Gattinoni L PMID: 32228035 PMCID: PMC7233352 DOI: 10.1164/rccm.202003-0817LE Abstract In northern Italy, an overwhelming number of patients with coronavirus disease (COVID-19) pneumonia and acute respiratory failure have been admitted to our ICUs. Attention is primarily focused on increasing the number of beds, ventilators, and intensivists brought to bear on the [...]

Authors: Wang J, Najizadeh N, Moore EE, McIntyre RC, Moore PK, Veress LA PMID: 32267998 PMCID: PMC7262152 DOI: 10.1111/jth.14828 Abstract A prothrombotic coagulopathy is commonly found in critically ill COVID-19 patients with acute respiratory distress syndrome (ARDS). A unique feature of COVID-19 respiratory failure is a relatively preserved lung compliance and high Alveolar-arterial oxygen gradient, [...]

Authors: Villar J, Confalonieri M, Pastores SM, Meduri GU PMID: 32426753 PMCID: PMC7188431 DOI: 10.1097/CCE.0000000000000111 Abstract In December 2019, pneumonia associated with the novel coronavirus disease 2019 (COVID-19) emerged in Wuhan, China. On March 14, 2020, the World Health Organization (WHO) declared the coronavirus outbreak a pandemic with confirmed cases in 127 countries. This unprecedented [...]

Authors: Boretti A, Banik BK PMID: 32322486 PMCID: PMC7172861 DOI: 10.1016/j.phanu.2020.100190 Abstract The recent outbreak of Covid19 has required urgent treatments for numerous patients. No suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of WHO therapies of choice, that are two antivirals developed for other pathologies, is controversial. Therefore, alternative approaches [...]

Authors: Gattinoni L, Chiumello D, Rossi S PMID: 32299472 PMCID: PMC7160817 DOI: 10.1186/s13054-020-02880-z Abstract Even though it can meet the ARDS Berlin definition, the COVID-19 pneumonia is a specific disease with peculiar phenotypes. Its main characteristic is the dissociation between the severity of the hypoxemia and the maintenance of relatively good respiratory mechanics. Indeed, the [...]

Authors: Henry MB, Lippi G PMID: 32279018 PMCID: PMC7118619 DOI: 10.1016/j.jcrc.2020.03.011 Abstract The novel coronavirus disease 2019 (COVID-19) can induce acute respiratory distress syndrome (ARDS), which can progress to refractory pulmonary failure. In such cases, extracorporeal membrane oxygenation (ECMO) may be considered as a rescue therapy. In a study of ECMO for ARDS in patients [...]

Authors: Meduri GU, Bridges L, Shih MC, Marik PE, Siemienluk RA, Kocak M PMID: 26508525 Abstract PURPOSE: To investigate the effect of prolonged glucocorticoid treatment for patients with acute respiratory distress syndrome (ARDS). METHODS: We conducted two sets of intention-to-treat analyses: (1) a primary analysis of individual patients' data (IPD) of four randomized controlled trials [...]

Authors: Ichikado K, Muranaka H, Gushima Y, Kotani T, Nader HM, Fujimoto K et al. PMID: 22382117 PMCID: PMC3293132 DOI: 10.1136/bmjopen-2011-000545 Abstract Objectives: To examine whether the extent of fibroproliferative changes on high-resolution CT (HRCT) scan influences prognosis, ventilator dependency and the associated outcomes in patients with early acute respiratory distress [...]

Authors: Ichikado K, Suga M, Muranka H, Gushima Y, Miyakawa H PMID: 16293804 DOI: 10.1148/radiol.2373041515 Abstract Purpose: To retrospectively evaluate whether the thin-section computed tomographic (CT) appearance has prognostic value for prediction of mortality, number of ventilator-free days (ie, days without mechanical ventilation), and 28-day risk of barotrauma in patients with a clinically early stage [...]

Authors: Gattinoni L, Pesenti A PMID: 15812622 DOI: 10.1007/s00134-005-2627-z Abstract Background: The "baby lung" concept originated as an offspring of computed tomography examinations which showed in most patients with acute lung injury/acute respiratory distress syndrome that the normally aerated tissue has the dimensions of the lung of a 5- to 6-year-old child (300-500 g aerated [...]