Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin.

Authors: Supady A, Taccone FS, Lepper PM, Ziegeler S, Staudacher DL PMID: 33648538 PMCID: PMC7919616 DOI: 10.1186/s13054-021-03486-9 Abstract Survival of coronavirus disease 2019 (COVID-19) patients with severe respiratory failure treated with veno-venous extracorporeal membrane oxygenation (V-V ECMO) ranges around 60%, according to recent studies. Initial recommendations for the use of V-V [...]

Authors: Caplan M, Goutay J, Bignon A, Jaillette E, Favory R PMID: 33093279 DOI: 10.1097/CCM.0000000000004711 Abstract Objectives: Treating acute respiratory failure in patients with coronavirus disease 2019 is challenging due to the lack of knowledge of the underlying pathophysiology. Hypoxemia may be explained in part by the loss of hypoxic pulmonary vasoconstriction. The present study [...]

Authors: Zaid Y, Guessous F, Puhm F, Elhamdani W, Chentoufi L, Morris AC PMID: 33560374 PMCID: PMC7846461 DOI: 10.1182/bloodadvances.2020003513 Abstract In addition to preserving homeostasis and contributing to immunity, platelets may exhibit a dysregulated state, in acute respiratory distress syndrome (ARDS) and potentially exacerbate lung injury.Although thrombocytopenia has been associated with increased mortality in ARDS,and [...]

Authors: Hashemian SM, Shafigh N, Afzal G, Jamaati H, Tabarsi P, Marjani M PMID: 33358260 PMCID: PMC7834188 DOI: 10.1016/j.pulmoe.2020.10.017 Abstract Background: In December 2019, pneumonia associated with a novel coronavirus (COVID-19) was reported in Wuhan, China. Acute respiratory distress syndrome (ARDS) is the most frequently observed complication in COVID-19 patients with high mortality rates. Objective [...]

Authors: Bagate F, Tuffet S, Masi P, Perier F, Razazi K PMID: 33150525 PMCID: PMC7641257 DOI: 10.1186/s13613-020-00769-2 Abstract Background: In COVID-19 patients with severe acute respiratory distress syndrome (ARDS), the relatively preserved respiratory system compliance despite severe hypoxemia, with specific pulmonary vascular dysfunction, suggests a possible hemodynamic mechanism for VA/Q mismatch, as hypoxic vasoconstriction alteration. [...]

Authors: Tomazini BM, Maia IS, Cavalcanti AB, Berwanger O, Rosa RG, Veiga VC PMID: 32876695 PMCID: PMC7489411 DOI: 10.1001/jama.2020.17021 Abstract Importance: Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone use might attenuate lung injury in these patients. Objective: To determine [...]

Authors: Kim SY, Jin W, Sood A, Montgomery DW, Grant OC, Fuster MM PMID: 32653452 PMCID: PMC7347485 DOI: 10.1016/j.antiviral.2020.104873 Abstract Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and continues to spread around the globe at an unprecedented rate. To date, no effective therapeutic is available to fight its associated disease, [...]

Authors: Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S PMID: 32167524 PMCID: PMC7070509 DOI: 10.1001/jamainternmed.2020.0994 Abstract Importance: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been [...]

Authors: De Maio A, Hightower LE PMID: 32424591 PMCID: PMC7232923 DOI: 10.1007/s12192-020-01121-0 Abstract The current coronavirus disease 2019 (COVID-19) pandemic has become an unprecedented challenge for the healthcare system worldwide, with an overwhelming number of patients requiring clinical attention and an unacceptably high mortality rate within critical care facilities. COVID-19 is caused by a novel [...]