Authors: Zhang X, Song Y, Ci X, An N, Ju Y PMID: 19109745 DOI: 10.1007/s00011-008-8007-8 Abstract Objective and design: To investigate whether ivermectin, a semi-synthetic derivative of a family of macrocyclic lactones could inhibit lipopolysaccharide (LPS)-induced inflammation in vivo and in vitro. Materials and methods: C57BL/6 mice were administered ivermectin (or saline) orally and challenged [...]

Authors: Heaney RP, Armas LA, Shary JR, Bell NH, Binkley N, Hollis BW PMID: 18541563 DOI: 10.1093/ajcn/87.6.1738 Abstract Background: Neither the efficiency of the 25-hydroxylation of vitamin D nor the steady state relation between vitamin D(3) and 25-hydroxyvitamin D [25(OH)D] has been studied in humans. Objective: We aimed to examine the relation between serum vitamin [...]

Authors: Elenkov IJ PMID: 15265778 DOI: 10.1196/annals.1321.010 Abstract Evidence accumulated over the last 5-10 years indicates that glucocorticoids (GCs) inhibit the production of interleukin (IL)-12, interferon (IFN)-gamma, IFN-alpha, and tumor necrosis factor (TNF)-alpha by antigen-presenting cells (APCs) and T helper (Th)1 cells, but upregulate the production of IL-4, IL-10, and IL-13 by Th2 cells. Through [...]

Authors: Ichikado K, Suga M, Muranka H, Gushima Y, Miyakawa H PMID: 16293804 DOI: 10.1148/radiol.2373041515 Abstract Purpose: To retrospectively evaluate whether the thin-section computed tomographic (CT) appearance has prognostic value for prediction of mortality, number of ventilator-free days (ie, days without mechanical ventilation), and 28-day risk of barotrauma in patients with a clinically early stage [...]

Authors: Gattinoni L, Pesenti A PMID: 15812622 DOI: 10.1007/s00134-005-2627-z Abstract Background: The "baby lung" concept originated as an offspring of computed tomography examinations which showed in most patients with acute lung injury/acute respiratory distress syndrome that the normally aerated tissue has the dimensions of the lung of a 5- to 6-year-old child (300-500 g aerated [...]

Authors: Edwards G PMID: 14975065 PMCID: PMC2147658 DOI: 10.1186/1475-2883-2-S1-S8 Abstract The macrocyclic lactone ivermectin (Mectizan(R)) is widely used for the control of human filarial infections, particularly as a donated product for onchocerciasis and lymphatic filariasis. In the case of control of lymphatic filariasis in Africa, it is used in combination with donated albendazole. In areas [...]

Authors: Pan H, Peto R, Karim QA, Alejandria M, Henao-Restrepo AM PMID: 33264556 PMCID: PMC7727327 DOI: 10.1056/NEJMoa2023184 Abstract Background: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 (Covid-19). Methods: We randomly assigned inpatients with Covid-19 [...]

Authors: Busund R, Koukline V, Utrobin U, Nedashkovsky E PMID: 12373468 DOI: 10.1007/s00134-002-1410-7 Abstract Objective: To determine the therapeutic efficacy and safety of plasmapheresis in the treatment of patients with severe sepsis and septic shock. Design: Prospective, randomised, clinical trial with a planned, midstudy, interim analysis. Setting: Intensive care unit in a university hospital in [...]

Authors: Ichikado K, Suga M, Muller NL, Tangiguchi H, Kondoh Y, Akira M PMID: 12045132 DOI: 10.1164/rccm.2106157 Abstract This study compared high-resolution computed tomography (CT) findings between 10 survivors and 21 nonsurvivors of acute interstitial pneumonia and evaluated whether the CT findings were predictive of patients' response to treatment. The survivor and nonsurvivor groups with [...]

Authors: Shodell M, Siegal FP PMID: 11544466 DOI: 10.1067/mai.2001.117928 Abstract Glucocorticoids are strongly immunosuppressive and are associated with reactivation of some intracellular infections. The plasmacytoid dendritic cell is a rare blood mononuclear cell detected through its production of IFN-alpha in response to herpes simplex virus and by surface immunophenotyping. We here report that steroid administration [...]