Authors: Menezes RR, Godin AM, Rodrigues FF, Coura GM, Melo IS, Brito AM PMID: 28958614 DOI: 10.1016/j.pharep.2017.04.011 Abstract Background: The effects induced by thiamine and riboflavin, isolated or in association with corticosteroids, in models of chronic inflammation are not known. Thus, we evaluated the effect induced by these B vitamins, isolated or in association with [...]

Authors: Jiang P PMID: 27753792 DOI: 10.1097/SHK.0000000000000769 Abstract Hypomagnesemia is commonly seen but frequently overlooked in critically ill patients in intensive care unit (ICU). However, the strength and consistency of the effect of hypomagnesemia on outcomes in critically ill patients remain controversial. In this report, we performed a systematic review and [...]

Authors: Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J PMID: 27940189 DOI: 10.1016/j.chest.2016.11.036 Abstract Background: The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. Methods: In this retrospective before-after clinical study, we compared the outcome and clinical course of [...]

Authors: Mallat J, Lemyze M, Thevenin D PMID: 27293820 PMCID: PMC4885988 DOI: 10.21037/jtd.2016.04.32 Abstract Thiamine was the first B vitamin to be identified and is also referred to as vitamin B1. It is a water-soluble vitamin that is an indispensable constituent of cellular metabolism. A lack of this vitamin can, therefore, be potentially life-threatening. Thiamine [...]

Authors: Meduri GU, Bridges L, Shih MC, Marik PE, Siemienluk RA, Kocak M PMID: 26508525 Abstract PURPOSE: To investigate the effect of prolonged glucocorticoid treatment for patients with acute respiratory distress syndrome (ARDS). METHODS: We conducted two sets of intention-to-treat analyses: (1) a primary analysis of individual patients' data (IPD) of four randomized controlled trials [...]

Although the broad-spectrum anti-parasitic effects of the avermectin derivative ivermectin are well documented, its anti-inflammatory activity has only recently been demonstrated. For over 25 years, ivermectin has been used to treat parasitic infections in mammals, with a good safety profile that may be attributed to its high affinity to invertebrate neuronal ion channels and its inability to cross the blood-brain barrier in humans and other mammals. Numerous studies report low rates of adverse events, as an oral treatment for parasitic infections, scabies and head lice. Ivermectin has been used off-label to treat diseases associated with Demodex mites, such as blepharitis and demodicidosis. New evidence has linked Demodex mites to rosacea, a chronic inflammatory disease. Ivermectin has recently received FDA and EU approval for the treatment of adult patients with inflammatory lesions of rosacea, a disease in which this agent has been shown to be well tolerated. After more than 25 years of use, ivermectin continues to provide a high margin of safety for a growing number of indications based on its anti-parasitic and anti-inflammatory activities.

Authors: Al-Jassim KB, Jawad AA, Al-Masoudi EA, Majeed SK Abstract The objective of this study was to assess the effects of repeated administration of ivermectin alone or with the combination of Vitamin C on kidney function and histopathological effects on kidney and lung of rabbits. Total of 48 mature female rabbits were used in this [...]

Authors: Thomas BJ, Porritt RA, Hertzog PJ, Bardin PG PMID: 25417801 PMCID: PMC5384105 DOI: 10.1038/srep07176 Abstract Glucocorticosteroids (GCS) are used on a daily basis to reduce airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). This treatment is usually escalated during acute disease exacerbations, events often associated with virus infections. We examined the impact [...]

Authors: Lin OA, Karim ZA, Vemana HP, Espinosa EV, Khasawneh FT PMID: 24466319 PMCID: PMC3900701 DOI: 10.1371/journal.pone.0087026 Abstract There is considerable interest in defining new agents or targets for antithrombotic purposes. The 5-HT2A receptor is a G-protein coupled receptor (GPCR) expressed on many cell types, and a known therapeutic target for many disease states. This [...]

Authors: Wittich CM, Burkle CM, Lanier WL PMID: 22877654 PMCID: PMC3538391 DOI: 10.1016/j.mayocp.2012.04.017 Abstract The term off-label drug use (OLDU) is used extensively in the medical literature, continuing medical education exercises, and the media. Yet, we propose that many health care professionals have an underappreciation of its definition, prevalence, and implications. This article introduces and [...]