Authors: Winslow RL, Zhou J, Windle EF, Nur I, Lall R, Ji C PMID: 34737194 PMCID: PMC8646974 DOI: 10.1136/thoraxjnl-2021-218035 Abstract Background: Continuous positive airways pressure (CPAP) and high-flow nasal oxygen (HFNO) are considered 'aerosol-generating procedures' in the treatment of COVID-19. Objective: To measure air and surface environmental contamination with SARS-CoV-2 virus when CPAP and HFNO [...]

Authors: Oskotsky T, Maric I, Tang A, Oskotsky B, Wong RJ, Sirota M PMID: 34779847 PMCID: PMC8593759 DOI: 10.1001/jamanetworkopen.2021.33090 Abstract Importance: Antidepressant use may be associated with reduced levels of several proinflammatory cytokines suggested to be involved with the development of severe COVID-19. An association between the use of selective serotonin reuptake inhibitors (SSRIs)-specifically fluoxetine [...]

Authors: Reis G, Moreira-Silva EA, Silva DC, Thabane L, Guyatt GH, Mills EJ PMID: 34717820 PMCID: PMC8550952 DOI: 10.1016/S2214-109X(21)00448-4 Abstract Background: Recent evidence indicates a potential therapeutic role of fluvoxamine for COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we aimed to assess the efficacy of fluvoxamine versus placebo in preventing hospitalisation [...]

Authors: Avendano-Sola C, Ramos-Martinez A, Munez-Rubio E, Ruiz-Antoran B, de Molina RM PMID: 34473652 PMCID: PMC8516461 DOI: 10.1172/JCI152740 Abstract BACKGROUND. Passive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19. Evidence from controlled clinical trials is inconclusive. METHODS. We conducted a randomized, open-label, controlled clinical trial at 27 hospitals in Spain. Patients had [...]

Authors: Peterson DJ. PMID: Abstract Keywords: Source: https://ago.nebraska.gov/sites/ago.nebraska.gov/files/docs/opinions/21-017_0.pdf Archive: https://archive.is/EoVhB

This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19).

Authors: Xin Y, Martin K, Morais CC, Gerard SE, Abate N, Sidhu U et al. PMID: 33938714 PMCID: PMC8448902 DOI: 10.1097/CCM.0000000000005071 Abstract Objectives: It is not known how lung injury progression during mechanical ventilation modifies pulmonary responses to prone positioning. We compared the effects of prone positioning on regional lung aeration in late versus early [...]

Authors: Reddy MP, Subramaniam A, Afroz A, Billah B, Lim ZJ, Wong SN PMID: 33927120 PMCID: PMC8439644 DOI: 10.1097/CCM.0000000000005086 Abstract Objectives: Several studies have reported prone positioning of nonintubated patients with coronavirus diseases 2019-related hypoxemic respiratory failure. This systematic review and meta-analysis evaluated the impact of prone positioning on oxygenation and clinical outcomes. Design and [...]

Authors: Barbaro RP, MacLaren G, Boonstra PS, Iwashyna TJ, Slutsky AS PMID: 34599878 PMCID: PMC8480964 DOI: 10.1016/S0140-6736(21)01960-7 Abstract Background: Over the course of the COVID-19 pandemic, the care of patients with COVID-19 has changed and the use of extracorporeal membrane oxygenation (ECMO) has increased. We aimed to examine patient selection, treatments, outcomes, and ECMO centre [...]

Authors: Nogues X, Overjero D, Pineda-Moncus M, Bouillon R PMID: 34097036 PMCID: PMC8344647 DOI: 10.1210/clinem/dgab405 Abstract Context: COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. Objective: This work aims to elucidate the effect [...]