Authors: Zaid Y, Puhm F, Allaeys I, Naya A, Oudghiri M PMID: 32938299 PMCID: PMC7641188 DOI: 10.1161/CIRCRESAHA.120.317703 Abstract Rationale: In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute to the lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated in thrombosis. Moreover, [...]

Until treatment and vaccine for coronavirus disease-2019 (COVID-19) becomes widely available, other methods of reducing infection rates should be explored. This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity rates.

Authors: Jans DA, Wagstaff KM PMID: 32942671 PMCID: PMC7564151 DOI: 10.3390/cells9092100 Abstract The small molecule macrocyclic lactone ivermectin, approved by the US Food and Drug Administration for parasitic infections, has received renewed attention in the last eight years due to its apparent exciting potential as an antiviral. It was identified in a high-throughput chemical screen [...]

Authors: Salton F, Confalonieri P, Santus P, Harari S, Scala R, Lanini S et al. PMID: 33072814 PMCID: PMC7543560 DOI: 10.1093/ofid/ofaa421 Abstract Background: In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated with significant morbidity and mortality. Severe dysregulated systemic inflammation is the [...]

Authors: Hottz ED, Azevedo-Quintanilha Ig, Palhinha L, Teixeira L, Barreto EA PMID: 32678428 PMCID: PMC7483437 DOI: 10.1182/blood.2020007252 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel coronavirus has rapidly achieved pandemic proportions causing remarkably increased morbidity and mortality around the [...]

Authors: Swargiary A DOI: https://doi.org/10.21203/rs.3.rs-73308/v1 Abstract Purpose: COVID-19, caused by SARS-CoV2 virus is a contagious disease affecting millions of lives throughout the globe. Currently, there are no clinically approved drugs for SARS-CoV2 although some drugs are undergoing clinical trials. The present study investigates the binding property of ivermectin on four important drug targets, spike protein, [...]

Authors: Bassetti M, Kollef MH, Timsit JF PMID: 32902729 PMCID: PMC7479998 DOI: 10.1007/s00134-020-06219-8 Abstract Are critically ill patients with coronavirus disease 2019 (COVID-19) at high risk of bacterial and fungal superinfections developing on the top of the viral infection in the lung or in other body sites? And from which organisms? Answering these apparently simple [...]

Authors: Hekimian G, Kerneis M, Zeitouni M, Cohen-Aubart F, Chommeloux J PMID: 32910974 PMCID: PMC7476896 DOI: 10.1016/j.chest.2020.08.2099 Abstract Hyperinflammatory shock was described recently in children during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The clinical presentation of these patients involved fever, cutaneous rash, abdominal symptoms, distributive shock, and acute cardiac injury. This multisystem [...]

Authors: Tan CW, Ho LP, Kalimuddin S, Cherng BP, Teh YE PMID: 33039952 PMCID: PMC7832811 DOI: 10.1016/j.nut.2020.111017 Abstract Objectives: The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B12 (DMB) compared with those who did not. We hypothesized [...]

Authors: DiNicolantonio JJ, Barroso-Arranda J, McCarty M PMID: 32895293 PMCID: PMC7476419 DOI: 10.1136/openhrt-2020-001350 Abstract Ivermectin, on the WHO’s List of Essential Medications, has been in clinical use since 1981 as an orally and topically active agent for treating a range of parasitic infections in humans, including river blindness and lymphatic filariasis. It is also widely [...]