Authors: Arslan B, Ergun NU, Topuz S, Semerci SY, Suner N. DOI: 10.2139/ssrn.3682517 Abstract Background: While waiting for vaccine, hygiene measures, social distance and personal protective equipment are the only basic protection against Novel Coronavirus. However, these are not sufficient to protect healthcare workers.This study aimed to evaluate if quercetin and vitamin C could be [...]

Authors: Clausen TM, Sandoval DR, Spliid CB, PiHl J, Painter CD, Thacker BE et al. PMID: 32970989 PMCID: PMC7489987 DOI: 10.1016/j.cell.2020.09.033 Abstract We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding [...]

Authors: Abou-Arab O, Huette P, Debouvries F, Dupont H, Jounieaux V PMID: 33183348 PMCID: PMC7661015 DOI: 10.1186/s13054-020-03371-x Abstract The role of inhaled nitric oxide (iNO) in the management of severe hypoxia due to coronavirus disease 2019 (Covid-19) is a subject of debate. Despite the lack of clinical data, the surviving sepsis campaign recommended the use [...]

Authors: Haymet A, Bassi GL, Fraser JF PMID: 33170330 PMCID: PMC7652914 DOI: 10.1007/s00134-020-06314-w Abstract In 2020, a new pandemic caused by SARS-CoV-2 was declared, and since the first cases of coronavirus disease 2019 (COVID-19), clinicians had to apply different modes of respiratory support, previously used on patients with severe respiratory failure from other etiologies. In [...]

Authors: Patterson BK, seethamraju H, Dhody K, Corley MJ, Kazempour K, Lalezari J et al. PMID: 33186704 PMCID: PMC7654230 DOI: 10.1016/j.ijid.2020.10.101 Abstract Objective: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global pandemic. Emerging results indicate a dysregulated immune response. Given the role of CCR5 in immune cell migration and inflammation, [...]

Authors: Bagate F, Tuffet S, Masi P, Perier F, Razazi K PMID: 33150525 PMCID: PMC7641257 DOI: 10.1186/s13613-020-00769-2 Abstract Background: In COVID-19 patients with severe acute respiratory distress syndrome (ARDS), the relatively preserved respiratory system compliance despite severe hypoxemia, with specific pulmonary vascular dysfunction, suggests a possible hemodynamic mechanism for VA/Q mismatch, as hypoxic vasoconstriction alteration. [...]

Authors: Shi Z, Puyo CA PMID: 33177829 PMCID: PMC7649937 DOI: 10.2147/TCRM.S273700 Abstract The novel coronavirus disease (COVID-19) is caused by a virus (SARS-Cov-2) and is known for inducing multisystem organ dysfunction associated with significant morbidity and mortality. Current therapeutic strategies for COVID-19 have failed to effectively reduce mortality rate, especially for elderly patients. A newly [...]

Authors: Payen D DOI:10.1097/CCM.0000000000004765 Abstract OBJECTIVES: Respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality have been identified as critically important core outcomes by more than 9300 patients, health professionals, and the public from 111 countries in the global coronavirus disease 2019 core outcome set initiative. The aim of this project was to [...]

COVID-19 patients suffer from the lack of curative therapy. Hence, there is an urgent need to try repurposed old drugs on COVID-19. Methods Randomized controlled study on 70 COVID-19 patients (48 mild-moderate, 11 severe, and 11 critical patients) treated with 200ug/kg PO of Ivermectin per day for 2-3 days along with 100mg PO doxycycline twice per day for 5-10 days plus standard therapy; the second arm is 70 COVID-19 patients (48 mild-moderate and 22 severe and zero critical patients) on standard therapy. The time to recovery, the progression of the disease, and the mortality rate were the outcome-assessing parameters.

Authors: Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N et al. PMID: 33142125 PMCID: PMC7585632 DOI: 10.1016/j.clinimag.2020.10.035 Abstract Objectives: We performed a systematic review and meta-analysis of the prevalence of chest CT findings in patients with confirmed COVID-19 infection. Methods: Systematic review of the literature was performed using PubMed, Scopus, Embase, [...]