Authors: Shu C, Feng S, Cui Q, Cheng S, Wang Y PMID: 34353036 DOI: 10.21037/apm-21-640 Abstract Background: Previous studies have reported that C reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in Coronavirus disease 2019 (COVID-19) patients are significantly increased, and their progressive increases are clinical warning indicators of severe and critical severity. [...]

Authors: Tomassetti F, Nuccetelli M, Sarubbi S, Gisone F, Ciotti M PMID: 34339963 PMCID: PMC8313542 DOI: 10.1016/j.intimp.2021.108013 Abstract The antibody response to SARS-CoV-2 has not yet fully defined, but the availability of sensitive and specific serological assays is crucial to observe the presence of specific antibodies against the human receptor binding domain (S-RBD) and high [...]

Authors: Perrella F, Coppola F, Petrone A, Platells C, Montesarchio D, Ravagnan G PMID: 34356672 PMCID: PMC8301781 DOI: 10.3390/biom11071048 Abstract In the search for new therapeutic strategies to contrast SARS-CoV-2, we here studied the interaction of polydatin (PD) and resveratrol (RESV)-two natural stilbene polyphenols with manifold, well known biological activities-with Spike, the viral protein essential [...]

Authors: Zhou L, Shin S Abstract Small fiber neuropathy (SFN) is common and can be associated with many medical conditions, including reports of an association with COVID-19. A Dutch study suggests a prevalence of 52.95 per 100,000 population that increases with age.1 Standardized diagnostic criteria for SFN are not fully established and skin biopsy [...]

Authors: Ahorsu DK, Adjaottor ES, Lam BY PMID: 34202739 PMCID: PMC8301762 DOI: 10.3390/brainsci11070840 Abstract This systematic review and meta-analysis aggregated and examined the treatment effect of non-invasive brain stimulation (NIBS) (transcranial direct current stimulation and transcranial magnetic stimulation) on cognitive functions in people with traumatic brain injury (TBI). A systematic search was conducted using databases [...]

Authors: Colunga Biancatelli RM, Solopov P, Sharlow E, Lazo J, Marik PE, Catravas J PMID: 34156871 PMCID: PMC8384477 DOI: 10.1152/ajplung.00223.2021 Abstract Acute lung injury (ALI) leading to acute respiratory distress syndrome is the major cause of COVID-19 lethality. Cell entry of SARS-CoV-2 occurs via the interaction between its surface spike protein (SP) and angiotensin-converting enzyme-2 [...]

Authors: Ahmadi R, Salari S, Reihani H, Eslami S. PMID: PMC8358331 DOI: 10.1002/fsn3.2226 Abstract Background: Curcumin, a natural polyphenolic compound, is proposed as a potential treatment option for patients with coronavirus disease by inhibiting the entry of virus to the cell, encapsulation of the virus and viral protease, as well as modulating various cellular signaling [...]

Authors: Gold JE, Okyay R, Licht WE, Hurley DJ PMID: 34204243 PMCID: PMC8233978 DOI: 10.3390/pathogens10060763 Abstract Coronavirus disease 2019 (COVID-19) patients sometimes experience long-term symptoms following resolution of acute disease, including fatigue, brain fog, and rashes. Collectively these have become known as long COVID. Our aim was to first determine long COVID prevalence in 185 [...]

Authors: DiPierro F, Derosa G, Maffioli P, Togni S, Riva A PMID: 34135619 PMCID: PMC8197660 DOI: 10.2147/IJGM.S318720 Abstract Background: Quercetin, a well-known naturally occurring polyphenol, has recently been shown by molecular docking, in vitro and in vivo studies to be a possible anti-COVID-19 candidate. Quercetin has strong antioxidant, anti-inflammatory, immunomodulatory, and antiviral properties, and it [...]

Authors: Pont G, Pastorino L, Manfredini M, Ozben T, Oliva G, Kaleci S PMID: 34061414 PMCID: PMC8209953 DOI: 10.1002/jcla.23798 Abstract Background: Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR C677 T gene [...]