Authors: Buras JA, Holt D, Orlow D, Belikoff B, Pavildes S, Reenstra WR PMID: 16932233 DOI: 10.1097/01.CCM.0000239438.22758.E0 Abstract Objective: This study was performed to determine whether hyperbaric oxygen (HBO2) therapy is protective in cecal ligation and puncture (CLP)-induced sepsis and if protection is dependent on oxygen dosing. We also wished to determine whether HBO2 affected [...]

Authors: Sotelo J, Briceno E, Lopez-Gonzalez MA PMID: 16520474 DOI: 10.7326/0003-4819-144-5-200603070-00008 Abstract Background: Malignant cell clones resistant to chemotherapy and radiotherapy frequently lead to treatment failure in patients with glioblastoma multiforme. Preliminary studies suggest that adding chloroquine to conventional therapy may improve treatment outcomes. Objective: To examine the effect of adding chloroquine to conventional therapy [...]

Authors: Zoger S, Svedlund J, Holgers KM PMID: 16415703 DOI: 10.1097/01.jcp.0000195111.86650.19 Abstract Objective: The relationship between tinnitus and anxiety and depressive disorders has been frequently alluded to, but there are few studies on antidepressants in the treatment of tinnitus, and the efficacy of sertraline on severe refractory tinnitus has not been reported. Method: Consecutive tinnitus [...]

Authors: Bahmad FM, Venosa AR, Oliveira CA PMID: 17260879 Abstract Severe disabling tinnitus (SDT) refers to a symptom severe enough to disrupt affected patients' routine and keep them from performing their daily activities. SDT of a predominantly central origin has been treated successfully with benzodiazepines and GABAergic drugs. Our aim was to test the control [...]

Authors: Levenson CW PMID: 16491668 DOI: 10.1111/j.1753-4887.2006.tb00171.x Abstract Low serum zinc levels have been linked to major depression. Furthermore, zinc treatment has been shown to have an antidepressant effect. With the hope of understanding the role of zinc in mood disorders, recent work has begun to explore possible mechanisms of zinc action on serotonin uptake [...]

Authors: Nowak G, Szewczyk B, Pilc A PMID: 16382189 Abstract Unsatisfactory clinical efficacy and a variety of adverse effects of current antidepressant drugs have incited search for better therapy. Zinc, an antagonist of the glutamate/N-methyl-D-aspartate (NMDA) receptor, exhibits antidepressant-like activity in rodent tests/models of depression. Similarly to antidepressants, zinc induces brain derived neurotrophic factor (BDNF) [...]

Authors: Berg K, Bolt G, Andersen H, Owen TC PMID: 11506740 DOI: 10.1089/10799900152434330 Abstract During the last decade, various zinc salts have been used against the common cold syndrome, which is known to be initiated by respiratory viruses, particularly rhinoviruses. Using rhinovirus as the challenge virus, we investigated whether zinc salts [...]

Authors: Bayar N, Boke B, Turan E, Belgin E PMID: 11771024 DOI: 10.2310/7070.2001.19597 Abstract We investigated the effect of amitriptyline, a tricyclic antidepressant, on patients with subjective tinnitus. The study group consisted of 37 adult patients admitted to the Ear, Nose, and Throat and Audiology Department of Hacettepe University. The amitriptyline group consisted of 20 [...]

The macromolecular permeability of cultured bovine aortic, bovine venous, and human umbilical vein endothelial cell monolayers was decreased significantly in culture medium containing L-ascorbic acid (Asc Acid; 0.01-0.1 mM) and L-ascorbic acid 2-phosphate (Asc 2-P). Dithiothreitol, which shows reducing activity equivalent to that of Asc Acid, did not affect endothelial permeability. Asc Acid induced a sixfold increase in collagen synthesis by the endothelial cells. The coexistence of L-azetidine 2-carboxylic acid, an inhibitor of collagen synthesis, attenuated the effect of Asc 2-P in a dose-dependent manner. Another collagen synthesis inhibitor, ethyl-3,4-dihydroxybenzoate, also inhibited collagen synthesis and increased endothelial permeability. The decrease in permeability of the endothelial monolayer was dependent on a reduction of the permeability coefficient of the endothelial monolayer. These findings indicate that endothelial barrier function is stimulated by Asc Acid via an increase in collagen synthesis.

Authors: Sullivan M, Katon W, Russo J, Dobie R, Sakai C PMID: 8215728 Abstract Objective: To determine whether the antidepressant, nortriptyline, is effective for treatment of depression, tinnitus-related disability, and tinnitus symptoms in patients with severe chronic tinnitus. Design: A 12-week, double-blind, randomized controlled trial. Setting: A university otolaryngology clinic. Patients: Ninety-two subjects with severe [...]