Authors: Gutierrez S, Svahn SL, Johansson ME PMID: 31614433 PMCID: PMC6834330 DOI: 10.3390/ijms20205028 Abstract Alterations on the immune system caused by omega-3 fatty acids have been described for 30 years. This family of polyunsaturated fatty acids exerts major alterations on the activation of cells from both the innate and the adaptive immune system, although [...]

Authors: Theoharides TC, Tsilioni I, Ren H PMID: 30884251 PMCID: PMC7003574 DOI: 10.1080/1744666X.2019.1596800 Abstract An increasing number of patients present with multiple symptoms affecting many organs including the brain due to multiple mediators released by mast cells. These unique tissue immune cells are critical for allergic reactions triggered by immunoglobulin E (IgE), but are also [...]

Authors: Theoharides TC, Tsilioni I, Ren H PMID: 30884251 PMCID: PMC7003574 DOI: 10.1080/1744666X.2019.1596800 Abstract An increasing number of patients present with multiple symptoms affecting many organs including the brain due to multiple mediators released by mast cells. These unique tissue immune cells are critical for allergic reactions triggered by immunoglobulin E (IgE), but are also [...]

Authors: Ma W, Zhang J, Guo L, Wang Y, Lu S, Wang Z et al. PMID: 30956636 PMCID: PMC6449667 Abstract Macrophages are important mediators of inflammatory cardiovascular diseases, and various macrophage phenotypes exert opposite effects during inflammation. In our previous study, we proved that suppressed androgen receptor (AR) alleviated inflammation during experimental autoimmune myocarditis (EAM). [...]

Authors: Beckman JA PMID: 30560579 PMCID: PMC6516871 doi: 10.1002/14651858.CD004437.pub5 AbstractBackgroundThrombolytic therapy is usually reserved for patients with clinically serious or massive pulmonary embolism (PE). Evidence suggests that thrombolytic agents may dissolve blood clots more rapidly than heparin and may reduce the death rate associated with PE. However, there are still concerns about the possible risk [...]

Authors: Becerra-Diaz M, Strickland AB, Keselman A, Heller NM PMID: 30305328 PMCID: PMC6219904 DOI: 10.4049/jimmunol.1800352 Abstract Allergic asthma is a disease initiated by a breach of the lung mucosal barrier and an inappropriate Th2 inflammatory immune response that results in M2 polarization of alveolar macrophages (AM). The number of M2 macrophages in the airway correlates [...]

Authors: Toljan K, Vrooman B PMID: 30248938 PMCID: PMC6313374 DOI: 10.3390/medsci6040082 Abstract Naltrexone and naloxone are classical opioid antagonists. In substantially lower than standard doses, they exert different pharmacodynamics. Low-dose naltrexone (LDN), considered in a daily dose of 1 to 5 mg, has been shown to reduce glial inflammatory response by modulating Toll-like receptor 4 [...]

Authors: Plantone D, Koudriavtseva T PMID: 29737455 DOI: 10.1007/s40261-018-0656-y Abstract The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), [...]

Authors: Kiechl S, Pechlaner R, Willeit P, Notdurfier M, Paulweber B, Willeit K et al. PMID: 29955838 DOI: 10.1093/ajcn/nqy102 Abstract Background: Spermidine administration is linked to increased survival in several animal models. Objective: The aim of this study was to test the potential association between spermidine content in diet and mortality in humans. Design: This [...]

Authors: Saba A, Vaidya PJ, Chavhan VB, Achlerkar A, Leuppi J PMID: 32476885 PMCID: PMC7170064 DOI: 10.36141/svdld.v35i1.6393 Abstract There are no specific data on the management of pulmonary fibrosis post-H1N1 ARDS. We present the cases of three patients who responded positively to treatment with pirfenidone, azithromycin and prednisolone. Three males, aged 40, 45 and 59 [...]