Authors: Spagnolo P, Balestro E, Aliberti S, Cocconcelli E, Biondini D, Casa GD PMID: 32422177 PMCID: PMC7228737 DOI: 10.1016/S2213-2600(20)30222-8 Abstract As of May 6, 2020, nearly 3·7 million people have been infected and around 260 000 people have died from coronavirus disease 2019 (COVID-19) worldwide.1 Almost all COVID-19-related serious consequences feature pneumonia.2 In the first large [...]

Authors: Patterson BK, seethamraju H, Dhody K, Corley MJ, Pang AP PMID: 32511656 PMCID: PMC7277012 DOI: 10.1101/2020.05.02.20084673 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is now pandemic with nearly three million cases reported to date. Although the majority of COVID-19 patients experience only mild or moderate [...]

Authors: Theoharides TC PMID: 32339387 PMCID: PMC7267424 DOI: 10.1002/biof.1633 Abstract The new coronavirus (severe acute pulmonary syndrome [SARS]‐CoV‐2) originated in China, where it spread rapidly, and has reached pandemic proportions because of its high rate of infectivity as well as high morbidity and mortality, associated with COVID‐19. This coronavirus infects by first binding to the [...]

Authors: Gassen NC, Papies J, Bajaj T, Emanuel J, Wechmann K, Heinz DE et al. doi: https://doi.org/10.1101/2020.04.15.997254 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health and the world economy, especially because no approved specific drugs or vaccines are available. Pharmacological modulation of metabolism-dependent cellular pathways such as autophagy [...]

Authors: Xu TT, Li H, Dai Z, Lau GK, Li BY, Zhu WL et al. PMID: 32268299 PMCID: PMC7185103 DOI: 10.18632/aging.103035 Abstract The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. However, the mechanism is still confused. An aging model, the senescence accelerated mouse-8 (SAMP8), was used in this [...]

Authors: Chai YS, Chen YQ, Lin SH, Xie K, Wang CJ, Yang YZ. PMID: 32004976 DOI: 10.1016/j.biopha.2020.109946 Abstract Objectives: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. Curcumin has been reported to be an anti-inflammatory factor through enhancing the function [...]

Authors: deCabo R, Mattson MP PMID: 31881139 DOI: 10.1056/NEJMra1905136 Abstract Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity. Keywords: fasting, intermittent fasting, health [...]

Authors: de Moreuil C, Alavi Z, Pasquier E PMID: 31633823 PMCID: PMC6983516 DOI: 10.1111/bcp.14131 Abstract Recurrent miscarriage (RM) and vasculoplacental disorders, such as preeclampsia (PE), affect women of childbearing age worldwide. Vascular endothelial dysfunction and immunological impairment are associated with both RM and PE. To date, there is no effective or optimal therapeutic approach for [...]

Authors: Shukla AM, Shukla AW PMID: 31844421 PMCID: PMC6905642 DOI: 10.7573/dic.2019-9-1 Abstract Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney [...]

Authors: Bawazeer MA, Theoharides TC PMID: 31669588 DOI: 10.1016/j.ejphar.2019.172760 Abstract Mast Cells (MCs) are critical for allergic reactions but also play important roles in inflammation, following stimulation by non-allergic triggers such as cytokines. Upon stimulation, MCs secrete numerous newly synthesized mediators, but the mechanism of the release of chemokines, which are important in the pathogenesis [...]