Quercetin, a well-known naturally occurring polyphenol, has recently been shown by molecular docking, in vitro and in vivo studies to be a possible anti-COVID-19 candidate. Quercetin has strong antioxidant, anti-inflammatory, immunomodulatory, and antiviral properties, and it is characterized by a very high safety profile, exerted in animals and in humans. Like most other polyphenols, quercetin shows a very low rate of oral absorption and its clinical use is considered by most of modest utility. Quercetin in a delivery-food grade system with sunflower phospholipids (Quercetin Phytosome®, QP) increases its oral absorption up to 20-fold.

Authors: Hannan MA PMID: 34073784 doi: 10.3390/nu13061784 Abstract Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The [...]

Authors:da Silva JK, Figueirdo PL, Byler KG, setzer WN. PMID:PMC7279430 DOI: 10.3390/ijms21103426 Abstract Essential oils have shown promise as antiviral agents against several pathogenic viruses. In this work we hypothesized that essential oil components may interact with key protein targets of the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A molecular docking analysis was [...]

Authors: Rattis BA, Ramos SG, Celes MR. PMID: PMC8138567 DOI: 10.3389/fphar.2021.675287 Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease that rapidly spread throughout the world leading to high mortality rates. Despite the knowledge of previous diseases caused by viruses of the same family, such as MERS and SARS-CoV, management and treatment of patients with [...]

After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within clinical trials.

Authors:Seet RC, Quek AM, Ooi DS, Sengupta S, Koo CY. PMID:PMC8056783 DOI: 10.1016/j.ijid.2021.04.035 Abstract Background: We examined whether existing licensed pharmacotherapies could reduce the spread of coronavirus disease 2019 (COVID-19). Methods: An open-label parallel randomized controlled trial was performed among healthy migrant workers quarantined in a large multi-storey dormitory in Singapore. Forty clusters (each defined [...]

Authors: Karimi A, Naeini F, Azar VA, Hasanzadeh M. PMID: 33940332 DOI: 10.1016/j.phymed.2021.153567 Abstract Background: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological actions including free radical scavenging and antioxidant activities. Quercetin, one of the most extensively distributed [...]

Authors:Nain Z, Rana HK, Lio P, Islam SM, Summers MA, Moni MA. PMID: PMC7454314 DOI: 10.1093/bib/bbaa173 Abstract The novel coronavirus (2019-nCoV) has recently emerged, causing COVID-19 outbreaks and significant societal/global disruption. Importantly, COVID-19 infection resembles SARS-like complications. However, the lack of knowledge about the underlying genetic mechanisms of COVID-19 warrants the development of prospective control [...]

Authors: Wimalawansa SJ. PMID: Abstract Globally, the prevalence of vitamin D deficiency is high, and the incidence is rising. This common micronutrient disorder is easily reversible; so, as the associated morbidity and mortality among affected people. The incidences of vitamin D deficiency continue to increase and have become a pandemic, mostly because of insufficient [...]

Authors:Teshome A, Adane A, Girma B, Mekonnen ZA. PMID:PMC7973108 doi: 10.3389/fpubh.2021.624559 Abstract Background: Coronavirus disease (COVID-19) is a respiratory and systemic disorder caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or novel Coronavirus (nCoV). To date, there is no proven curative treatment for this virus; as a result, prevention remains to be the best [...]