Authors: Yoshihara T, Shimada K, Fukao K, Sai E, Matsumori R, Alshahi H PMID: 25925976 DOI: 10.1253/circj.CJ-14-0471 Abstract Background: Dietary intake of ω3 polyunsaturated fatty acids (ω3-PUFAs) reduces progression of atherosclerosis and prevents future cardiovascular events. Macrophages are key players in the pathogenesis of aortic aneurysm. The effects of ω3-PUFAs on abdominal aortic aneurysm [...]

Authors: Serhan CN PMID: 24899309 PMCID: PMC4263681 doi: 10.1038/nature13479 Abstract Advances on mechanisms in resolution of acute inflammation uncovered a new genus of pro-resolving lipid mediators that include separate families of molecules: lipoxins, resolvins, protectins and maresins, collectively coined specialized pro-resolving mediators (SPM). Synthetic SPM possess potent bioactions when administered in vivo. In animal experiments, [...]

Authors: Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD PMID: 25122198 PMCID: PMC4409786 DOI: 10.1158/2159-8290.CD-13-1010 Abstract TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastases. Through the generation of mouse [...]

Authors: Valentova K, Vrba J, Bancirova M, Ulrichova J. PMID: 24680690 DOI: 10.1016/j.fct.2014.03.018 Abstract The flavonoid isoquercitrin (quercetin-3-O-β-d-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and "enzymatically modified (α-glucosylated) isoquercitrin" (EMIQ). Pure isoquercitrin can now [...]

Authors: Ishima T, Fujita Y, Hashimoto K PMID: 24508523 DOI: 10.1016/j.ejphar.2014.01.064 Abstract The sigma-1 receptor chaperone located in the endoplasmic reticulum (ER) may be implicated in the mechanistic action of some antidepressants. The present study was undertaken to examine whether new antidepressant drugs interact with the sigma-1 receptor chaperone. First, we examined the effects of [...]

Authors: Gonzalez-Castejoxn M, Visioli F, Rodrigues-Casado A PMID: 22946853 DOI: 10.1111/j.1753-4887.2012.00509.x Abstract Dandelion (Taraxacum officinale Weber) is a member of the Asteraceae (Compositae) family, native to Europe but widely distributed in the warmer temperate zones of the Northern Hemisphere. Dandelion and its parts are habitually consumed as plant foods in several areas of the world, [...]

Authors: Wambier CG, de Pina Almeida Prado Junior B, Pereira CS, Foss NT PMID: 22892774 DOI: 10.1590/s0365-05962012000400012 Abstract A focused and commented review on the impact of dermatologic diseases and interventions in the solidary act of donating blood is presented to dermatologists to better advise their patients. This is a review of current Brazilian technical [...]

Authors: Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A. PMID: 22470478 PMCID: PMC3314669 DOI: 10.1371/journal.pone.0033805 Abstract Mast cells are immune cells critical in the pathogenesis of allergic, but also inflammatory and autoimmune diseases through release of many pro-inflammatory cytokines such as IL-8 and TNF. Contact dermatitis and photosensitivity are skin conditions that involve [...]

Authors: Titos E, Rius B, Gonzalez-Periz A, Lopez-Vicario C, Arroyo V, Claria J PMID: 22013115 DOI: 10.4049/jimmunol.1100225 Abstract We recently demonstrated that ω-3-polyunsaturated fatty acids ameliorate obesity-induced adipose tissue inflammation and insulin resistance. In this study, we report novel mechanisms underlying ω-3-polyunsaturated fatty acid actions on adipose tissue, adipocytes, and stromal vascular cells (SVC). [...]

Authors: Bismuth-Evenzal Y, Gonopolsky Y, gurwitz D, Iancu I, Weizman A PMID: 21893349 DOI: 10.1016/j.jad.2011.08.013 Abstract Background: Chronic treatment with selective serotonin reuptake inhibitors (SSRIs) reduces the risk and severity of cardiovascular diseases. SSRIs block the serotonin transporter, thereby inhibiting serotonin (5-HT) uptake into presynaptic neurons as well as into platelets [...]