Authors: Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Pollak U PMID: 20586571 DOI: 10.3109/15563650.2010.495348 Abstract Introduction: Colchicine is used mainly for the treatment and prevention of gout and for familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut distinction between nontoxic, toxic, and lethal doses, causing substantial [...]

Authors: Heaney RP, Armas LA, Shary JR, Bell NH, Binkley N, Hollis BW PMID: 18541563 DOI: 10.1093/ajcn/87.6.1738 Abstract Background: Neither the efficiency of the 25-hydroxylation of vitamin D nor the steady state relation between vitamin D(3) and 25-hydroxyvitamin D [25(OH)D] has been studied in humans. Objective: We aimed to examine the relation between serum vitamin [...]

Authors: Chen L, Li J, Luo C, Liu H, Xu W, Chen G. PMID: 17046271 PMCID: PMC7125754 DOI: 10.1016/j.bmc.2006.09.014 Abstract The 3C-like protease (3CL(pro)) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is one of the most promising targets for discovery of drugs against SARS, because of its critical role in the viral life cycle. In [...]

Authors: Maurer-Spurej E, Pittendreigh C, Solomons K PMID: 14691577 DOI: 10.1160/TH03-05-0330 Abstract Clinical depression has been proposed to be an independent risk factor for cardiovascular disease. While it is suggested that selective serotonin reuptake inhibitors (SSRIs) reduce the risk of acute cardiovascular problems of depressed patients, the effect of SSRIs on platelets, the only blood [...]

Authors: Shiraishi T, Nakagawa Y. PMID: 12011519 DOI: 10.1159/000057723 AbstractObjective: Encouragement of gargling is important for the control of opportunistic and community-acquired infections. In hospitals, a povidone-iodine (PVP-I) gargle is used frequently. However, at pharmacies in the community a variety of gargles containing various ingredients are now available. In view of this, we conducted a [...]

Authors: Hartter S, Wang X, Weigmann H, Friedberg T, Arand M PMID: 11270913 DOI: 10.1097/00004714-200104000-00008 Abstract Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is [...]

Authors: Javors MA, Houston JP, Tekell JL, Brannan SK, Frazer A PMID: 11343600 DOI: 10.1017/S146114570000198X Abstract Drugs thought to be selective inhibitors of either the uptake of serotonin (5-HT) or norepinephrine (NE) are known to be effective antidepressants. In general, a relative selectivity for NE vs. 5-HT uptake inhibition greater than 50-fold in vitro is [...]