Authors: Cao J, Forrest CJ, Zhang X PMID: 25451075 PMCID: PMC7113785 DOI: 10.1016/j.antiviral.2014.11.010 Abstract With the recent emergence of Middle East Respiratory Syndrome coronavirus in humans and the outbreak of devastating porcine epidemic diarrhea coronavirus in swine, therapeutic intervention is urgently needed. However, anti-coronavirus drugs currently are not available. In an effort to assist rapid [...]

Authors: Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD PMID: 25122198 PMCID: PMC4409786 DOI: 10.1158/2159-8290.CD-13-1010 Abstract TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastases. Through the generation of mouse [...]

Authors: Rossignol JF PMID: 25108173 PMCID: PMC7113776 DOI: 10.1016/j.antiviral.2014.07.014 Abstract Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the treatment of influenza. A Phase 2b/3 clinical trial recently published in The Lancet Infectious Diseases found that oral administration of nitazoxanide [...]

Authors: Valentova K, Vrba J, Bancirova M, Ulrichova J. PMID: 24680690 DOI: 10.1016/j.fct.2014.03.018 Abstract The flavonoid isoquercitrin (quercetin-3-O-β-d-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and "enzymatically modified (α-glucosylated) isoquercitrin" (EMIQ). Pure isoquercitrin can now [...]

Authors: Ishima T, Fujita Y, Hashimoto K PMID: 24508523 DOI: 10.1016/j.ejphar.2014.01.064 Abstract The sigma-1 receptor chaperone located in the endoplasmic reticulum (ER) may be implicated in the mechanistic action of some antidepressants. The present study was undertaken to examine whether new antidepressant drugs interact with the sigma-1 receptor chaperone. First, we examined the effects of [...]

Authors: Wambier CG, de Pina Almeida Prado Junior B, Pereira CS, Foss NT PMID: 22892774 DOI: 10.1590/s0365-05962012000400012 Abstract A focused and commented review on the impact of dermatologic diseases and interventions in the solidary act of donating blood is presented to dermatologists to better advise their patients. This is a review of current Brazilian technical [...]

Authors: Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A. PMID: 22470478 PMCID: PMC3314669 DOI: 10.1371/journal.pone.0033805 Abstract Mast cells are immune cells critical in the pathogenesis of allergic, but also inflammatory and autoimmune diseases through release of many pro-inflammatory cytokines such as IL-8 and TNF. Contact dermatitis and photosensitivity are skin conditions that involve [...]

Authors: Titos E, Rius B, Gonzalez-Periz A, Lopez-Vicario C, Arroyo V, Claria J PMID: 22013115 DOI: 10.4049/jimmunol.1100225 Abstract We recently demonstrated that ω-3-polyunsaturated fatty acids ameliorate obesity-induced adipose tissue inflammation and insulin resistance. In this study, we report novel mechanisms underlying ω-3-polyunsaturated fatty acid actions on adipose tissue, adipocytes, and stromal vascular cells (SVC). [...]

Authors: Bismuth-Evenzal Y, Gonopolsky Y, gurwitz D, Iancu I, Weizman A PMID: 21893349 DOI: 10.1016/j.jad.2011.08.013 Abstract Background: Chronic treatment with selective serotonin reuptake inhibitors (SSRIs) reduces the risk and severity of cardiovascular diseases. SSRIs block the serotonin transporter, thereby inhibiting serotonin (5-HT) uptake into presynaptic neurons as well as into platelets [...]

Authors: Sathyapalan T, Manuchehri AM, Thatcher NJ, Rigby AS, Chapman T. PMID: 21325465 DOI: 10.1210/jc.2010-2255 Abstract Context: There is concern whether soy phytoestrogens may affect thyroid function. If true, soy phytoestrogens may be expected to have a greater impact in subjects with subclinical hypothyroidism. Objective: The primary aim was to determine the effect of soy [...]