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Authors: Rahimi HR, Nedaeinia R, Shamloo AS, Nikdoust S. PMID: 27516979 PMCID: PMC4967834 Abstract Objective: Curcumin is extracted from Curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: Curcumin
Authors: Wang W, Sun C, Mao L, Ma P, Liu F, Yang J. doi: https://doi.org/10.1016/j.tifs.2016.07.004 Abstract Background Quercetin, one of the most well-known flavonoids, has been included in human diet for a long history. The use of quercetin has been widely associated with a great number of health benefits, including antioxidant, anti-inflammatory, antiviral and anticancer [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: quercetin
Authors: Leyva-Lopez N, Gutierrez-Grijalva EP, Ambriz-Perez D. PMID: PMC4926454 DOI: 10.3390/ijms17060921 Abstract High levels of cytokines, such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6, are associated with chronic diseases like rheumatoid arthritis, asthma, atherosclerosis, Alzheimer's disease and cancer; therefore cytokine inhibition might be an important target for the treatment of these diseases. Most [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: Cytokines, flavonoids
Authors: van Zuuren EJ, Fedorowicz Z, Schoones J PMID: 27225981 PMCID: PMC6457957 DOI: 10.1002/14651858.CD007628.pub4 Abstract Background: Female pattern hair loss (FPHL), or androgenic alopecia, is the most common type of hair loss affecting women. It is characterised by progressive shortening of the duration of the growth phase of the hair with successive hair cycles, and [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV
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Authors: Rossignol JF PMID: 27095301 PMCID: PMC7102735 DOI: 10.1016/j.jiph.2016.04.001 Abstract Nitazoxanide is a broad-spectrum antiviral agent undergoing clinical development for treatment of influenza and other viral respiratory infections. Nitazoxanide exhibits in vitro activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and other coronaviruses, inhibiting expression of the viral N protein. Nitazoxanide also suppresses production of [...]
Categories: I-CARE Early Covid
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Authors: Seale LR, Eglini AN, McMichael AJ PMID: 27050696 Abstract 5 α-reductase inhibitors such as finasteride and dutasteride have been studied for the treatment of hair loss in men, with finasteride being the only Food and Drug Administration-approved treatment. Increasingly, in recent years, off-label use of these drugs has been employed in the treatment of [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV
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Authors: Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S et al. PMID: 26999194 doi: 10.3390/nu8030167 Abstract In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities; as well as attenuating lipid peroxidation, platelet [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-PREVENT, I-RECOVER Post-Vaccine
Tags: quercetin
Authors: Kircik LH, Del Rosso JQ, Layton AM, Schauber J PMID: 26954318 Abstract Although the broad-spectrum anti-parasitic effects of the avermectin derivative ivermectin are well documented, its anti-inflammatory activity has only recently been demonstrated. For over 25 years, ivermectin has been used to treat parasitic infections in mammals, with a good safety profile that may [...]
Categories: I-CARE Early Covid
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Authors: Yoshihara T, Shimada K, Fukao K, Sai E, Matsumori R, Alshahi H PMID: 25925976 DOI: 10.1253/circj.CJ-14-0471 Abstract Background: Dietary intake of ω3 polyunsaturated fatty acids (ω3-PUFAs) reduces progression of atherosclerosis and prevents future cardiovascular events. Macrophages are key players in the pathogenesis of aortic aneurysm. The effects of ω3-PUFAs on abdominal aortic aneurysm [...]
Categories: I-CARE Early Covid, I-CARE Flu and RSV, I-RECOVER Long Covid
Tags: Aortic Aneurysms, Omega-3
Authors: Serhan CN PMID: 24899309 PMCID: PMC4263681 doi: 10.1038/nature13479 Abstract Advances on mechanisms in resolution of acute inflammation uncovered a new genus of pro-resolving lipid mediators that include separate families of molecules: lipoxins, resolvins, protectins and maresins, collectively coined specialized pro-resolving mediators (SPM). Synthetic SPM possess potent bioactions when administered in vivo. In animal experiments, [...]
Tags: Inflammation