Authors: Das UN PMID: 32229155 PMCID: PMC7270578 doi: 10.1016/j.arcmed.2020.03.004 Abstract SARS-CoV-2, SARS and MERS are all enveloped viruses that can cause acute respiratory syndrome. Arachidonic acid (AA) and other unsaturated fatty acids (especially eicosapentaenoic acd, EPA and docosahexaenoic acid DHA) are known to inactivate enveloped viruses and inhibit proliferation of various microbial organisms. The pro-inflammatory [...]

Authors: Yang SN, Atkinson SC, Wang C, Lee A PMID: 32135219 DOI: 10.1016/j.antiviral.2020.104760 Abstract Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and dengue virus (DENV) represent a major burden for human health worldwide. Although RNA viruses replicate in the infected host cell cytoplasm, the nucleus is central to key stages of [...]

Authors: Moballegh Nasery M, Abadi B, Poormoghadam D, Zarrabi A, Keyhanvar P, Tavakol S et al. PMID: PMC7037405 DOI: 10.3390/molecules25030689 Abstract Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such [...]

Authors: Gutierrez S, Svahn SL, Johansson ME PMID: 31614433 PMCID: PMC6834330 DOI: 10.3390/ijms20205028 Abstract Alterations on the immune system caused by omega-3 fatty acids have been described for 30 years. This family of polyunsaturated fatty acids exerts major alterations on the activation of cells from both the innate and the adaptive immune system, although [...]

Authors: Kunnumakkara AB, Harsha C, Banik K, Vikkurthi R, Sailo BL, Bordoloi D PMID: 31361978 DOI: 10.1080/17425255.2019.1650914 Abstract Introduction: Since ancient times, turmeric has been used in several folklore remedies against various ailments. The principal component of turmeric is curcumin and its efficacy has been advocated in various in vitro, in vivo and clinical studies [...]

Riva A, Ronchi M, Petrangolini G, Bosisio S, Allegrini P. PMID: 30328058 PMCID: PMC6418071 DOI: 10.1007/s13318-018-0517-3 Abstract Background and objectives: The importance of quercetin and flavonoids in the diet and as food supplements is well known, and literature studies support their potential use to treat several human diseases. Many beneficial properties have been described [...]

Authors: Piacentini S, La Frazia S, Riccio A, Pedersen JZ, Topai A, Nicolotti O PMID: 29992955 PMCID: PMC6041319 DOI: 10.1038/s41598-018-28172-9 Abstract Paramyxoviridae, a large family of enveloped viruses harboring a nonsegmented negative-sense RNA genome, include important human pathogens as measles, mumps, respiratory syncytial virus (RSV), parainfluenza viruses, and henipaviruses, which cause some of the deadliest [...]

Authors: Cloutier N, Allaeys I, Marcoux G, Machius KR, Mailhot B PMID: 29386381 PMCID: PMC5816207 DOI: 10.1073/pnas.1720553115 Abstract There is a growing appreciation for the contribution of platelets to immunity; however, our knowledge mostly relies on platelet functions associated with vascular injury and the prevention of bleeding. Circulating immune complexes (ICs) contribute to both chronic [...]

Authors: Lee CR, Zeldin DC PMID: 26605933 PMCID: PMC5512422 doi: 10.1056/NEJMcibr1511280 Abstract Severe sepsis remains a major public health problem associated with poor clinical outcomes and substantial health care expenditures. Although the number of sepsis cases in the United States exceeds 750,000 per year and sepsis is associated with an estimated mortality rate of 20–30%, [...]

Authors: Rich GT. PMID: 28165426 doi: 10.3390/nu9020111 PMCID: PMC5331542 Abstract We have studied the uptake of quercetin aglycone into CaCo-2/TC7 cells in the presence and absence of mixed micelles that are present in the human small intestine. The micelles inhibited the transport of quercetin into the cells. To gain an understanding of why this is [...]