Authors: Alam MT, Murshed R, Bhiuyan E, Saber S, Alam RF, Robin RC. DOI:10.3329/jbcps.v38i0.47512 Abstract Background: A definitive treatment of SARS CoV-2 is yet toarrive and the human death toll rises exponentially globally.In this health emergency, it might be useful to look into theold therapies which could be effective against the virus. Invitro research showed [...]

Authors: Maurya DK DOI: 10.26434/chemrxiv.12630539.v1 D O I: 10.26434/chemrxiv.12630539.v1 [opens in a new tab] Abstract The current outbreak of the corona virus disease 2019 (COVID-19), has affected almost entire world and become pandemic now. Currently, there is neither any FDA approved drugs nor any vaccines available to control it. Very recently in Bangladesh, a group [...]

Authors: Hammock BD, Wang W, Gilligan MM, Panigrahy D PMID: 32650004 PMCID: PMC7340586 DOI: 10.1016/j.ajpath.2020.06.010 Abstract Severe coronavirus disease 2019 (COVID-19) symptoms, including systemic inflammatory response and multisystem organ failure, are now affecting thousands of infected patients and causing widespread mortality. Coronavirus infection causes tissue damage, which triggers the endoplasmic reticulum stress response and subsequent [...]

Authors: Gorial FI, Mashhadani S, Sayaly HM, Dakhil BD, AlMashhadani MM. doi: https://doi.org/10.1101/2020.07.07.20145979 Abstract Background To date no effective therapy has been demonstrated for COVID-19. In vitro, studies indicated that ivermectin (IVM) has antiviral effect. Objectives To assess the effectiveness of ivermectin (IVM) as add-on therapy to hydroxychloroquine (HCQ) and azithromycin (AZT) in treatment of [...]

Authors: Calis Z, Mogulkoc R, Baltaci AK. PMID: 31288717 DOI: 10.2174/1389557519666190617150051 Abstract The inflammatory process in the human body is a physiological response involving many cellular types and mediators. It results in scar formation to separate the damaged area from the surrounding healthy tissue. Because of increased blood-brain barrier permeability following inflammation, leukocytes infiltrate the [...]

Authors: Rahman MT PMID: 32834942 doi: 10.1016/j.hermed.2020.100382 Abstract An effective vaccine to prevent the SARS-CoV-2 causing COVID-19 is yet to be approved. Further there is no drug that is specific to treat COVID-19. A number of antiviral drugs such as Ribavirin, Remdesivir, Lopinavir/ritonavir, Azithromycin and Doxycycline have been recommended or are being used to treat [...]

Authors: Wessel L Abstract Researchers accused of killing patients after using a high dose to treat coronavirus infection Keywords: COVID-19, SARS-CoV2 Source: https://www.science.org/content/article/it-s-nightmare-how-brazilian-scientists-became-ensnared-chloroquine-politics Archive: https://archive.is/sD9SZ

Authors: Schultze A, Walker AJ, MacKenna B, Morten CE, Bhaskaran K, Brown JP doi: https://doi.org/10.1101/2020.06.19.20135491 Abstract Background Early descriptions of the coronavirus outbreak showed a lower prevalence of asthma and COPD than was expected for people diagnosed with COVID-19, leading to speculation that inhaled corticosteroids (ICS) may protect against infection with SARS-CoV-2, and development of [...]

Authors: Rajter JC, Sherman MS, Fatteh N, Vogel F, Sacks J, Rajter JJ. doi: https://doi.org/10.1101/2020.06.06.20124461 Abstract Importance No therapy to date has been shown to improve survival for patients infected with SARS-CoV-2. Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in vitro but clinical response has not been previously evaluated. Objective To determine [...]

Authors: Liadet L, Szabo C DOI:10.1186/s13054-020-03055-6 Abstract The pulmonary renin angiotensin (Ang) system (RAS) comprises two pathways whose balance is important for lung homeostasis. Endothelial ACE generates Ang II, acting on AT1 receptors to promote vasoconstriction and pro-inflammatory effects, whereas epithelial ACE2 cleaves Ang II into Ang1–7, acting on the Mas receptor to exert vasodilatory [...]