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Authors: Ahmed AK, Albalawi YS, Shora HA, Abelseed HK, Al-Kattan AN. DOI:10.37179/rijed.000005 Abstract ABSTRACT COVID-19 emerged in Wuhan, China in December 2019, reached epidemic proportions and spread globally as a serious life-threatening pandemic. SARS- Cov-2 is the causative virus that causes severe acute respiratory distress, pneumonia, respiratory failure, and septic shock leading to increased mortality. [...]
Categories: I-CARE Early Covid, MATH+
Authors: Castillo ME, Costa LM, Barrios JM, Diaz JF, Miranda JL, Bouillon R et al. PMID: 32871238 PMCID: PMC7456194 DOI: 10.1016/j.jsbmb.2020.105751 Abstract Objective: The vitamin D endocrine system may have a variety of actions on cells and tissues involved in COVID-19 progression especially by decreasing the Acute Respiratory Distress Syndrome. Calcifediol can rapidly increase serum [...]
Categories: I-CARE Early Covid, MATH+
Tags: Calcifediol, COVID-19
Authors:Vergara-Buenaventura A, Castro-ruiz C. PMID: PMC7428696 DOI: 10.1016/j.bjoms.2020.08.016 Abstract The proximity to the patient during dental care, high generation of aerosols, and the identification of SARS-CoV-2 in saliva have suggested the oral cavity as a potential reservoir for COVID-19 transmission. Mouthwashes are widely-used solutions due to their ability to reduce the number of microorganisms in [...]
Categories: I-CARE Early Covid, I-PREVENT
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Authors: De Flora S, Balansky R, La Maestra S PMID: 32780893 PMCID: PMC7436914 DOI: 10.1096/fj.202001807 Abstract COVID-19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a systemic inflammatory response, and an attack by the immune system. Moreover, an oxidative stress imbalance has [...]
Categories: I-CARE Early Covid, I-RECOVER Long Covid, I-RECOVER Post-Vaccine, MATH+
Tags: COVID-19, N-Acetylcysteine
Authors: Shakoor H, Feehan J, Dhaheri AS, Ali HI, Platat C, Ismail LC PMID: 33308613 PMCID: PMC7415215 DOI: 10.1016/j.maturitas.2020.08.003 Abstract The world is currently in the grips of the coronavirus disease (COVID-19) pandemic, caused by the SARS-CoV-2 virus, which has mutated to allow human-to-human spread. Infection can cause fever, dry cough, fatigue, severe pneumonia, respiratory [...]
Categories: I-CARE Early Covid
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Approximately 9 months of the severe acute respiratory syndrome coronavius-2 (SARS-CoV-2 [COVID-19]) spreading across the globe has led to widespread COVID-19 acute hospitalizations and death. The rapidity and highly communicable nature of the SARS-CoV-2 outbreak has hampered the design and execution of definitive randomized, controlled trials of therapy outside of the clinic or hospital.
Categories: I-CARE Early Covid
Tags: Ambulatory treatment, Anti-inflammatory, Anticoagulant, Antiviral, COVID-19, Critical care, Epidemiology, SARS-CoV-2
Authors: Cadegiani FA, Wambier CG, Goren A PMID: 32850920 PMCID: PMC7399048 DOI: 10.3389/fmed.2020.00453 Abstract At the onset of the COVID-19 pandemic, mortality following infection of severe acute respiratory coronavirus (SARS-CoV-2) was thought to be solely associated with aging and pre-existing conditions; however, as the pandemic ensued, several large scale epidemiological observations eluded to additional atypical [...]
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Authors: Varatharajah N doi: https://doi.org/10.20944/preprints202007.0516.v1 Abstract COVID-19 thromboembolic disease has brought all of us back to the drawing board. In COVID-19, pre-existing activated endothelium with increased Von Willebrand factor (VWF), low density lipoprotein (LDL) promoting “self-association” and “sticking” of long VWF strings to the vascular endothelial wall, suppressed ADAMTS13 cleavage of VWF, hypoxia induced upregulation [...]
Categories: I-CARE Early Covid
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Authors: Cadegiani FA, Goren A, Wambier CG PMID: 32721806 PMCID: PMC7363620 doi: 10.1016/j.mehy.2020.110112 Abstract In coronavirus disease-19 (COVID-19), four major factors have been correlated with worse prognosis: aging, hypertension, obesity, and exposure to androgen hormones. Angiotensin-converting enzyme-2 (ACE2) receptor, regulation of the renin-angiotensin-aldosterone system (RAAS), and transmembrane serine protease 2 (TMPRSS2) action are critical for [...]
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Authors: Chowdhury AT, Shahabz M, Karim MR, Islam J, Guo D, He D. DOI: https://doi.org/10.21203/rs.3.rs-38896/v1 Abstract Background The worldwide COVID-19 pandemic was caused by a newly discovered Coronavirus. The treatment methods for COVID-19 are emerging and rapidly evolving. Existing drugs, including Ivermectin and Hydroxychloroquine, offer the hope of effective treatment in early disease. In this [...]
Categories: I-CARE Early Covid, MATH+
Tags: COVID-19, Doxycyline, Hydroxychloroquine, ivermectin