Auhtors: Kumari N, Choi SH PMID: 35183252 PMCID: PMC8857848 DOI: 10.1186/s13046-022-02272-x Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent immunotherapy trials have produced suboptimal outcomes, with durable responses seen only in a small number of patients. The tumor microenvironment (TME) has been shown to be responsible for tumor immune escape and [...]

Auhtors: Vasim I, Majeed CN, DeBoer MD PMID: 35276989 PMCID: PMC8839325 DOI: 10.3390/nu14030631 Abstract Given the ongoing strain that the obesity epidemic has placed on public health outcomes, new and effective approaches to weight control are needed. One approach to improving weight and metabolic outcomes is intermittent fasting, which consists of multiple different timing schedules [...]

Auhtors: Kolawole OR, Kashfi K PMID: 35163356 PMCID: PMC8836048 DOI: 10.3390/ijms23031432 Abstract Acute inflammation or resolved inflammation is an adaptive host defense mechanism and is self-limiting, which returns the body to a state of homeostasis. However, unresolved, uncontrolled, or chronic inflammation may lead to various maladies, including cancer. Important evidence that links inflammation and cancer [...]

Auhtors: Pliss A, Kuzmin AN, Prasad PN, Mahajan SD PMID: 35049274 PMCID: PMC8790819 DOI: 10.1021/acschemneuro.1c00675 Abstract The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is increasingly attributed to mitochondrial dysfunction of brain microglia cells. However, the changes in biochemical content of mitochondria that drive the progression [...]

Auhtors: Cao X, Li Y, Wang Y, Yu T, Zhu C, Zhang X, Guan J PMID: 35041678 PMCID: PMC8765616 DOI: 10.1371/journal.pone.0261370 Abstract Breast cancer (BC) is one of the most common malignant tumors found in females. Previous studies have demonstrated that curcumin, which is a type of polyphenol compound extracted from Curcuma longa underground rhizome, [...]

Auhtors: Noman MZ, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, et al. PMID: 35053426 PMCID: PMC8774531 DOI: 10.3390/cells11020310 Abstract Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population of the immune system. They play a pivotal role in the establishment of the tumor microenvironment (TME). In the context of [...]

Auhtors: Ma T, Renz BW, Ilmer M, Koch D, Yang Y, Werner J, Bazhin AV PMID: 35053426 PMCID: PMC8774531 DOI: 10.3390/cells11020310 Abstract Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population of the immune system. They play a pivotal role in the establishment of the tumor microenvironment (TME). In the context of [...]

Auhtors: Moding EJ, Nabet BY, Alizadeh AA, Diehn M PMID: 34785539 PMCID: PMC8976700 DOI: 10.1158/2159-8290.CD-21-0634 Abstract Growing evidence demonstrates that circulating tumor DNA (ctDNA) minimal residual disease (MRD) following treatment for solid tumors predicts relapse. These results suggest that ctDNA MRD could identify candidates for adjuvant therapy and measure response to such treatment. Importantly, factors [...]

Auhtors: Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S PMID: 34858513 PMCID: PMC8632422 DOI: 10.1155/2021/8254344 Abstract Background: The global prevalence of stress is increasing. Stress adversely affects cognitive ability, sleep quality, and overall psychological well-being. Ashwagandha (Withania somnifera (L.) Dunal), an essential medicine in Ayurveda, is reportedly beneficial in reducing stress [...]

Auhtors: Abrams HR, Durbin S, Huang CX, Johnson SF, Nayak RK, Zahner GJ, Peppercorn J PMID: 34850932 DOI: 10.1093/tbm/ibab091 Abstract Financial toxicity describes the financial burden and distress that can arise for patients, and their family members, as a result of cancer treatment. It includes direct out-of-pocket costs for treatment and indirect costs such as [...]