Auhtors: Takeshige K, Baba M, Tsuboi S, Noda T, Ohsumi Y PMID: 1400575 PMCID: PMC2289660 DOI: 10.1083/jcb.119.2.301 Abstract For determination of the physiological role and mechanism of vacuolar proteolysis in the yeast Saccharomyces cerevisiae, mutant cells lacking proteinase A, B, and carboxypeptidase Y were transferred from a nutrient medium to a synthetic medium devoid of [...]

Auhtors: Israel BA, Schaeffer WI. PMID: 3654482 DOI: 10.1007/BF02621071 Abstract Using both normal and transformed rat liver epithelial cells to prepare cytoplasmic hybrids (cybrids) we have found evidence to support the theory that the cytoplasm from a normal cell can suppress tumorigenicity. A unique aspect of this study is that all of the cells utilized, [...]

Auhtors: Keys A, Mienotti A, Karvonen MJ, Aravanis C, Blackburn H, Buzina R, Keys MH PMID: 3776973 DOI: 10.1093/oxfordjournals.aje.a114480 Abstract In 15 cohorts of the Seven Countries Study, comprising 11,579 men aged 40-59 years and "healthy" at entry, 2,288 died in 15 years. Death rates differed among cohorts. Differences in mean age, blood pressure, serum [...]

Auhtors: Dawson M, Watson TR PMID: 3978024 PMCID: PMC1463790 DOI: 10.1111/j.1365-2125.1985.tb02617.x Abstract Four different dose forms of mebendazole were administered to human volunteers, and urine was collected and assayed for mebendazole and unconjugated metabolites of mebendazole. Oral administration of mebendazole as an oily suspension slightly enhances the bioavailability of the drug, however mebendazole is not [...]

Auhtors: Howell AN, Sagar R PMID: 276880 PMCID: PMC392552 DOI: 10.1073/pnas.75.5.2358 Abstract The effect of cytoplasm upon the expression of tumorigenicity was examined with a pair of mouse and a pair of Chinese hamster cell lines, in intraspecies cybrids formed by reciprocal fusions between either tumorigenic or nontumorigenic cells and cytoplasms derived from them. With [...]

Auhtors: Halma MT, Tuszynski J, Marik P PMID: 198801 PMCID: PMC431708 DOI: 10.1073/pnas.74.9.3735 Abstract A tumorigenic anchorage-dependent cell line (H-91) was established in culture from an azo-dye-induced rat ascites hepatoma. When grown in a glucose-containing medium the cells exhibit high rates of lactic acid production characteristic of rapidly growing tumor cells. However, when glucose is [...]

Auhtors: Szent-Gyorgyi A PMID: 268635 PMCID: PMC431314 DOI: 10.1073/pnas.74.7.2844 Abstract Complex living structures developed on our globe after the appearance of light and oxygen. In functions of these structures, solid state phenomena play a major role. The structural proteins were made into radicals by doping, the covalent incorporation of electron acceptors. This lent mobility to [...]

Auhtors: MacMahon B, Cole PE, Lin TM, Lowe CR, Mirra AP PMID: 5312521 PMCID: PMC2427645 Abstract An international collaborative study of breast cancer and reproductive experience has been carried out in 7 areas of the world. In all areas studied, a striking relation between age at first birth and breast cancer risk was observed. It [...]

Auhtors: Dayton S, Pearce ML, Hashimoto S, Fakler LJ, Hiscock E, Dixon WJ PMID: 13884081 DOI: 10.1056/NEJM196205172662001 Abstract This report describes a clinical trial, with domiciled male veterans, designed to determine whether a diet which lowers serum cholesterol concentration can prevent overt complications of coronary heart disease and other manifestations of atherosclerosis. Volunteers were allocated [...]

Auhtors: Page IH, Allen EV, Chamberlain FL, Keys A, Stamler J, Stare FJ PMID: 14447694 doi: https://doi.org/10.1161/01.CIR.23.1.133 Abstract no abstract available Source: https://www.ahajournals.org/doi/pdf/10.1161/01.cir.23.1.133 Archive: https://archive.is/5X2k2