Auhtors: Zulian E, Sartorato P, Benedini S, Baro G, Armanini D, Mantero F, Scaroni C PMID: 15816371 DOI: 10.1007/BF03345529 Abstract This prospective clinical trial was designed to assess the effects of a long-term therapy with spironolactone, with and without dietary-induced weight-loss, on clinical features, lipid profile and insulin levels in women with polycystic ovary syndrome [...]

Auhtors: Ahlstrom LH, Sparr Eskilsson C, Bjorklund E doi: https://doi.org/10.1016/j.trac.2004.09.004 Abstract Azo dyes, extensively used for coloring a variety of consumer goods, such as leather, clothes, food, and toys, can under certain conditions be reduced to form confirmed or suspected carcinogenic aromatic amines. This article gives an overview of the state of development of analytical [...]

Auhtors: D'Agostino DM, Bernardi P, Chieco-Bianchi L, Ciminale V PMID: 16096000 DOI: 10.1016/S0065-230X(05)94003-7 Abstract Molecular analyses of tumor virus-host cell interactions have provided key insights into the genes and pathways involved in neoplastic transformation. Recent studies have revealed that the human tumor viruses Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), human papillomavirus (HPV), hepatitis B [...]

Auhtors: Morgan G, Ward R, Barton M PMID: 15630849 DOI: 10.1016/j.clon.2004.06.007 Abstract Aims: The debate on the funding and availability of cytotoxic drugs raises questions about the contribution of curative or adjuvant cytotoxic chemotherapy to survival in adult cancer patients. Materials and methods: We undertook a literature search for randomised clinical trials reporting a 5-year [...]

Auhtors: Al-Hajj M, Clarke MF PMID: 15378087 DOI: 10.1038/sj.onc.1207947 Abstract Solid tumors arise in organs that contain stem cell populations. The tumors in these tissues consist of heterogeneous populations of cancer cells that differ markedly in their ability to proliferate and form new tumors. In both breast cancers and central nervous system tumors, cancer cells [...]

Auhtors: Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L, Jaenisch R PMID: 15289459 PMCID: PMC517407 DOI: 10.1101/gad.1213504 Abstract We have used nuclear transplantation to test whether the reprogramming activity of oocytes can reestablish developmental pluripotency of malignant cancer cells. We show here that the nuclei of leukemia, lymphoma, and breast cancer [...]

Auhtors: Chang ET, Montgomery SM, Richiardi L, Ehlin A, Ekbom A, Lambe M PMID: 15247136 Abstract Background: Epidemiologic evidence indicates that risk of Hodgkin's lymphoma (HL) in young adults is associated with correlates of delayed exposure to infection during childhood. In contrast, HL among children and older adults may be associated with earlier childhood infection. [...]

Auhtors: Vieth R PMID: 15225842 DOI: 10.1016/j.jsbmb.2004.03.038 Abstract The physiologic range for circulating 25-hydroxyvitamin D3 [25(OH)D; the measure of Vitamin D nutrient status] concentration in humans and other primates extends to beyond 200 nmol/L (>80 ng/mL). This biologic "normal" value is greater than current population norms for 25(OH)D. Concentrations of 25(OH)D that correlate with desirable [...]

Auhtors: Lasalvia-Prisco E, Cucchi S, Vázquez J, Lasalvia-Galante E, Golomar W, Gordon W. PMID: 14655024 DOI: 10.1007/s00280-003-0716-7 Abstract Purpose: It has been reported that insulin increases the cytotoxic effect in vitro of methotrexate by as much as 10,000-fold. The purpose of this study was to explore the clinical value of insulin as a potentiator of [...]

Auhtors: Alaee M, Arias P, Sjödin A, Bergman A PMID: 12850087 DOI: 10.1016/S0160-4120(03)00121-1 Abstract Brominated flame retardants (BFRs) are used in a variety of consumer products and several of those are produced in large quantities. These compounds have been detected in environmental samples, which can be attributed to the anthropogenic uses of these compounds. Brominated [...]