Auhtors: Martin RM, Middleton N, Gunnell D, Owen CG, Smith GD PMID: 16204694 DOI: 10.1093/jnci/dji291 Abstract Background: Having been breast-fed has been suggested to influence cancer risk in adulthood. We investigated associations between breast-feeding during infancy and adult cancer incidence and mortality in a cohort study and meta-analyses of published studies. Methods: The Boyd Orr [...]

Auhtors: Braun S, Vogl FD, Naume B, Janni W, Osborne MP, Coombes RC, et al. PMID: 16120859 DOI: 10.1056/NEJMoa050434 Abstract Background: We assessed the prognostic significance of the presence of micrometastasis in the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis. Methods: We combined individual patient data [...]

Auhtors: Singh KK, Kulawiec M, Still I, Desouki MM, Geradts J, Matsui SI PMID: 15979824 DOI: 10.1016/j.gene.2005.03.027 Abstract Mitochondrial dysfunction is a hallmark of cancer cells. Consistent with this phenotype mutations in mitochondrial genome have been reported in all cancers examined to date. However, it is not clear whether mitochondrial genomic status in human cells [...]

Auhtors: Ramanathan A, Wang C, Schreiber SL PMID: 15840712 PMCID: PMC1087961 DOI: 10.1073/pnas.0502267102 Abstract Weinberg and coworkers have used serial transduction of a human, primary fibroblast cell line with the catalytic domain of human telomerase, large T antigen, small T antigen, and an oncogenic allele of H-ras to study stages leading toward a fully transformed [...]

Auhtors: Harris SL, Levine AJ PMID: 15838523 DOI: 10.1038/sj.onc.1208615 Abstract The p53 pathway responds to stresses that can disrupt the fidelity of DNA replication and cell division. A stress signal is transmitted to the p53 protein by post-translational modifications. This results in the activation of the p53 protein as a transcription factor that initiates a [...]

Auhtors: Zea AH, Rodriguez PC, Atkins MB, Hernandez C, Signoretti S, Zabaleta J, et al. PMID: 15833831 DOI: 10.1158/0008-5472.CAN-04-4505 Abstract Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. These cells, described as macrophages or immature dendritic cells, deplete arginine and impair T cell [...]

Auhtors: Banting W Abstract In what's billed as the "world's first diet book," William Banting offered his strategy for losing weight. He ate four meals a day, didn't exercise much, drank alcohol, and swore off only a few foods. And, what's more, anyone familiar with current low-carb diets will find similar advice here -- advice [...]

Auhtors: Merrill RM, Fugal S, Novilla LB, Raphael MC PMID: 15721398 DOI: 10.1016/j.ygyno.2004.11.038 Abstract Objective: This paper provides a review of the literature associating maternal age at first birth and cancer. Potential mechanisms explaining associations between maternal age at first birth and cancer are also discussed. Method: Systematic review of English language literature using searches [...]

Auhtors: Yates JS, Mustian KM, Morrow GR, Gillies LJ, Padmanaban D, Atkins JN, et al. PMID: 15711946 DOI: 10.1007/s00520-004-0770-7 Abstract Goals of work: To assess complementary and alternative medicine (CAM) therapies being utilized by cancer patients during treatment and communication about CAM usage between the patient and physician. Patients and methods: Newly diagnosed cancer patients [...]

Auhtors: Berwick M, Armstrong BK, Ben-Porat L, Fine J, Kricker A, Eberle C, Barnhill R PMID: 15687362 DOI: 10.1093/jnci/dji019 Abstract Background: Melanoma incidence and survival are positively associated, both geographically and temporally. Solar elastosis, a histologic indicator of cutaneous sun damage, has also been positively associated with melanoma survival. Although these observations raise the possibility [...]