Auhtors: Sheng Y, Laister RC, Lemak A, Wu B, Tai E, Duan S, et al. Abstract Pirh2 (p53-induced RING-H2 domain protein; also known as Rchy1) is an E3 ubiquitin ligase involved in a negative-feedback loop with p53. Using NMR spectroscopy, we show that Pirh2 is a unique cysteine-rich protein comprising three modular domains. The protein [...]

Auhtors: Kilkkinen A, Rissanen H, Klaukka T, Pukkala E, Heliövaara M, Huovinen P, et al. PMID: 18704945 DOI: 10.1002/ijc.23622 Abstract Antibiotic use has been hypothesized to be associated with the risk of cancer but the evidence is sparse and inconsistent. The aim of the present study was to determine whether antibiotic use predicts the development [...]

Auhtors: Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN PMID: 18703489 PMCID: PMC2582368 DOI: 10.1194/jlr.M800319-JLR200 Abstract Otto Warburg first proposed that cancer originated from irreversible injury to mitochondrial respiration, but the structural basis for this injury has remained elusive. Cardiolipin (CL) is a complex phospholipid found almost exclusively in the inner mitochondrial membrane [...]

Auhtors: McGirt MJ, Chaichana KL, Gathinji M, Attenello F, Than K, Ruiz AJ, Olivi A PMID: 18797358 DOI: 10.1227/01.NEU.0000315282.61035.48 Abstract Objective: Patients with malignant brain astrocytomas are at high risk for developing hyperglycemia secondary to frequent corticosteroid administration. Several clinical studies have shown that hyperglycemia is associated with poor outcome in multiple disease states. Furthermore, [...]

Auhtors: Lee IM, Buchner DM PMID: 18562968 DOI: 10.1249/MSS.0b013e31817c65d0 Abstract Purpose: There is clear evidence that physical activity, including walking, has substantial benefits for health. This article, prepared as part of the proceedings of a conference on walking and health, discusses the type of walking that produces substantial health benefits, considers several methodological issues pertinent [...]

Auhtors: Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB PMID: 18505970 DOI: 10.1093/jnci/djn148 Abstract Despite nearly two decades of research investigating the use of dietary antioxidant supplementation during conventional chemotherapy and radiation therapy, controversy remains about the efficacy and safety of this complementary treatment. Several randomized clinical trials have demonstrated that [...]

Auhtors: Chida Y, Hamer M, Wardle J, Steptoe A PMID: 18493231 DOI: 10.1038/ncponc1134 Abstract A substantial body of research has investigated the associations between stress-related psychosocial factors and cancer outcomes. Previous narrative reviews have been inconclusive. In this Review, we evaluated longitudinal associations between stress and cancer using meta-analytic methods. The results of 165 studies [...]

Auhtors: Clippinger AJ, Bouchard MJ PMID: 18448529 PMCID: PMC2446973 DOI: 10.1128/JVI.00154-08 Abstract Over 350 million people are chronically infected with hepatitis B virus (HBV), and a significant number of chronically infected individuals develop primary liver cancer. HBV encodes seven viral proteins, including the nonstructural X (HBx) protein. The results of studies with immortalized or transformed [...]

Auhtors: Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ PMID: 18287387 DOI: 10.3322/CA.2007.0010 Abstract Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and [...]

Auhtors: Merhi M, Raynal H, Cahuzac E, Vinson F, Cravedi JP, Gamet-Payrastre L PMID: 17874193 DOI: 10.1007/s10552-007-9061-1 Abstract Objective: In this study we conducted a meta-analysis of 13 case-control studies that examined the occurrence of hematopoietic cancers in pesticide related occupations in order to undertake a qualitative and quantitative evaluation of a possible relationship. Methods: [...]