Auhtors: Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C PMID: 20427238 DOI: 10.1016/j.coph.2010.04.001 Abstract 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of vitamin D, is known to regulate calcium and phosphorus metabolism, thus being a key-player in bone-formation. However 1,25(OH)(2)D(3) also has a physiological role beyond its well-known role in skeletal homeostasis. Here, we [...]

Auhtors: Kvaavik E, Batty GD, Ursin G, Huxley R, Gale CR PMID: 20421558 DOI: 10.1001/archinternmed.2010.76 Abstract Background: Physical activity, diet, smoking, and alcohol consumption have been shown to be related to mortality. We examined prospectively the individual and combined influence of these risk factors on total and cause-specific mortality. Methods: The prospective cohort study included [...]

Auhtors: Nimptsch K, Rohrmann S, Kaaks R, Linseisen J PMID: 20335553 DOI: 10.3945/ajcn.2009.28691 Abstract Background: Anticarcinogenic activities of vitamin K have been observed in animal and cell studies. Objective: On the basis of the growth inhibitory effects of vitamin K as observed in a variety of cancer cell lines, we hypothesized that dietary intake of [...]

Auhtors: Schmid K, Kuwert T, Drexler H PMID: 20386676 PMCID: PMC2853156 DOI: 10.3238/arztebl.2010.0181 Abstract Background: Occupational medicine has long recognized radon to be a cause of lung cancer, especially among miners working under ground. Until recently, however, little scientific evidence was available about the risk to the general population caused by indoor radon. Methods: The [...]

Auhtors: Koduru S, Kumar R, Srinivasan S, Evers MB, Damodaran C PMID: 20053782 PMCID: PMC3041017 DOI: 10.1158/1535-7163.MCT-09-0771 Abstract Notch signaling plays a crucial role in the development of colon cancer; targeting the Notch pathway may sensitize colon cancers to various adjuvant agents. The focus of our current study is to identify natural compounds that target [...]

Auhtors: Pan PY, Ma G, Weber KJ, Ozao-Choy J, Wang G, Yin B, et al. PMID: 19996287 PMCID: PMC2805053 DOI: 10.1158/0008-5472.CAN-09-1882 Abstract Immune tolerance to tumors is often associated with accumulation of myeloid-derived suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In tumor-bearing mice, MDSCs can themselves facilitate the generation [...]

Auhtors: Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN PMID: 19969554 DOI: 10.1093/carcin/bgp280 Abstract Calorie restriction (CR) is arguably the most potent, broadly acting dietary regimen for suppressing the carcinogenesis process, and many of the key studies in this field have been published in Carcinogenesis. Translation of the knowledge gained from CR research [...]

Auhtors: Godsland IF PMID: 19922415 PMCID: PMC2782313 DOI: 10.1042/CS20090399 Abstract Experimental, epidemiological and clinical evidence implicates insulin resistance and its accompanying hyperinsulinaemia in the development of cancer, but the relative importance of these disturbances in cancer remains unclear. There are, however, theoretical mechanisms by which hyperinsulinaemia could amplify such growth-promoting effects as insulin may have, [...]

Auhtors: Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT PMID: 19896326 DOI: 10.1016/j.jpainsymman.2009.06.008 Abstract This study compared the efficacy of a tetrahydrocannabinol:cannabidiol (THC:CBD) extract, a nonopioid analgesic endocannabinoid system modulator, and a THC extract, with placebo, in relieving pain in patients with advanced cancer. In total, 177 patients with cancer pain, [...]

Auhtors: Yang C, Sudderth J, Dang T, Bachoo RG, McDonald JG, Deberardinis RJ PMID: 19826036 PMCID: PMC2764330 DOI: 10.1158/0008-5472.CAN-09-2266 Abstract Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc stimulates glutamine metabolism and renders cells dependent on glutamine to sustain viability ("glutamine addiction"), suggesting that treatments targeting glutamine metabolism might selectively kill c-Myc-transformed tumor [...]