Herbal and Nutraceutical Interventions for Osteoporosis: A Review of Effects on Bone Mineral Density

Objective: To review and summarize the current evidence on herbal and nutraceutical interventions for osteoporosis, focusing on their effects on bone mineral density (BMD). Methods: A literature search was conducted using Google Scholar to identify human clinical studies evaluating herbal and nutraceutical treatments for osteoporosis with BMD as an outcome measure. The search terms “Herbal treatment for osteoporosis” were used, and citations were scanned for additional relevant clinical trials. Results: The review identified several promising interventions for osteoporosis management. Calcium and vitamin D supplementation remained cornerstone treatments, showing significant improvements in BMD. Isoflavones and phytoestrogens, particularly genistein, rhizoma drynariae, and soy isoflavones, demonstrated positive effects on BMD through hormonal pathways. Traditional herbal remedies such as Rehmannia glutinosa and Cornus mas also showed potential in increasing BMD. Other notable interventions included antioxidants and minerals like selenium, magnesium, and vitamin C, which were associated with improved BMD in various skeletal sites. Conclusion: Herbal and nutraceutical treatments show promise in managing osteoporosis and improving BMD. However, their practical application is limited by the need for more extensive, high-quality clinical trials to establish efficacy, safety, and standardized dosing guidelines. Future research should focus on large-scale randomized controlled trials, clarification of mechanisms of action, and development of standardized formulations to support the integration of these alternative therapies into conventional osteoporosis management protocols.

Keywords: Osteoporosis, Bone Mineral Density, Herbal Medicine