After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within clinical trials. Areas of Uncertainty: The majority of trialed agents have failed to provide reproducible, definitive proof of efficacy in reducing the mortality of COVID-19 with the exception of corticosteroids in moderate to severe disease. Recently, evidence has emerged that the oral antiparasitic agent ivermectin exhibits numerous antiviral and anti-inflammatory mechanisms with trial results reporting significant outcome benefits. Given some have not passed peer review, several expert groups including Unitaid/World Health Organization have undertaken a systematic global effort to contact all active trial investigators to rapidly gather the data needed to grade and perform meta-analyses. Data Sources: Data were sourced from published peer-reviewed studies, manuscripts posted to preprint servers, expert meta-analyses, and numerous epidemiological analyses of regions with ivermectin distribution campaigns. Therapeutic Advances: A large majority of randomized and observational controlled trials of ivermectin are reporting repeated, large magnitude improvements in clinical outcomes. Numerous prophylaxis trials demonstrate that regular ivermectin use leads to large reductions in transmission. Multiple, large “natural experiments” occurred in regions that initiated “ivermectin distribution” campaigns followed by tight, reproducible, temporally associated decreases in case counts and case fatality rates compared with nearby regions without such campaigns. Conclusions: Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin. Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified.

The coordinated attack by Big Pharma, major media, and government agencies was meant to leave ivermectin beaten, bruised, and whimpering in the shadows, zapped of its power to do what it knew it could: Save lives.

Nebraska’s Attorney General issued an opinion on the “Prescription of Ivermectin and Hydroxychloroquine as Off-Label Medicines for the Prevention or Treatment of Covid-19.

"Does Ivermectin save lives? Absolutely. Does it alleviate suffering? Yes. Does it prevent deaths? Absolutely. And we cannot be silenced. We must speak for those who have no voice. Patients have a right to seek life saving care, and we should make this available to patients who want it."

In "Horse-Bleep: How 4 Calls on Animal Ivermectin Launched a False FDA-Media Attack," investigative reporters Pfeiffer and Bonvie dug up FDA emails documenting the start of the coordinated, mass propaganda campaign against IVM — and got The New York Times to correct its false reporting about it.

Remdesivir is (at best) useless against Covid-19. At worst, it is dangerous to patients who receive it.

Authors: Peterson DJ. PMID: Abstract Keywords: Source: https://ago.nebraska.gov/sites/ago.nebraska.gov/files/docs/opinions/21-017_0.pdf Archive: https://archive.is/EoVhB

TrialSite News provides clip of The Joe Rogan Experience where Dr. Sanjay Gupta admits CNN lied about ivermectin in horse deworming smear.

This TrialSiteNews investigation, reprinted with permission on the BIRD Group blog, describes the smear campaign launched by governmental regulatory bodies, mainstream media, and disinformation agents/fact-checkers against ivermectin.

Debunking the BBC debunk of ivermectin. U.K. Nurse/Teacher John Campbell Breaks Down the BBC’s “Reality Check” on Ivermectin by Using Science to Compare IVM to Molnupiravir.