Authors:Radujkovic A, Hippchen T, Tiwari-Heckler S, Dreher S, Merle U. PMID: PMC7551780 DOI: 10.3390/nu12092757 Abstract Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible [...]

Authors: Tan CW, Ho LP, Kalimuddin S, Cherng BP, Teh YE. PMID: 33039952 PMCID: PMC7832811 DOI: 10.1016/j.nut.2020.111017 Abstract Objectives: The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B12 (DMB) compared with those who did not. We hypothesized [...]

Authors: Tan CW, Ho LP, Kalimuddin S, Cherng BP, Teh YE PMID: 33039952 PMCID: PMC7832811 DOI: 10.1016/j.nut.2020.111017 Abstract Objectives: The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B12 (DMB) compared with those who did not. We hypothesized [...]

Authors:Israel A, Cicurel A, Feldhamer I, Dror Y, Giveon SM, Gillis D et al. doi: https://doi.org/10.1101/2020.09.04.20188268 Abstract BACKGROUND Recent studies suggest a link between vitamin D deficiency and Covid-19 infection. In our population we observe major differences in Covid-19 incidence in ethnic groups and genders in each group. METHODS We carried [...]

Authors:Rizzoli R. PMID: PMC7897606 DOI: 10.1007/s40520-020-01678-x Abstract Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, [...]

Vitamin D: modulator of the immune system. Current Opinion in Pharmacology 2010; 10:482-96. 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of vitamin D, is known to regulate calcium and phosphorus metabolism, thus being a key-player in bone-formation.

Authors:Carpagnano GE, Lecce V, Quaranta VN, Zito A, Buonamico E. PMID: PMC7415009 DOI: 10.1007/s40618-020-01370-x Abstract Purpose: Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease [...]

Auhtors: Heiskanen V, Pfiffner M, Partonen T doi: https://doi.org/10.1016/j.arr.2020.101089 Abstract Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast [...]

New research provides evidence of an impaired vitamin D gene signature in CD4+ T cells in patients with severe COVID-19. Mechanistically, it is shown that vitamin D alters the epigenetic landscape of CD4+ T cells, as well as inducing key transcription factors such as STAT3, BACH2 and JUN that reduce levels of IFN-γ and increase IL-10. These changes generate pro-resolving TH1 cells that may be beneficial in resolving or preventing severe COVID-19.

Authors: Henriquez MS, de Tejada Romero MJ PMID: 32486496 PMCID: PMC7352679 doi: 10.3390/nu12061617 Abstract Vitamin D deficiency is a global health problem due to its high prevalence and its negative consequences on musculoskeletal and extra-skeletal health. In our comparative review of the two exogenous vitamin D supplementation options most used in our care setting, we [...]