Authors: Howell AP, Parrett JL, Malcom DR PMID: 31766883 PMCID: PMC8256056 DOI: 10.1177/1932296819889638 Abstract Background: Intravenous vitamin C therapy has been associated with reduced mortality in patients with sepsis. Of potential concern with this therapy are falsely elevated point-of-care (POC) blood glucose values vs laboratory analyzed (LA) readings. The purpose of this study was to [...]

Authors: Fowler AA, Truwit JD, Hite D, Morris PE, DeWilde C, Priday A et al. PMID: 31573637 PMCID: PMC6777268 DOI: 10.1001/jama.2019.11825 Abstract Importance: Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis and acute respiratory distress syndrome (ARDS). Objective: To determine the effect of intravenous vitamin C infusion [...]

Authors: Stephenson E, Hooper MH, Marik PE DOI:https://doi.org/10.1016/j.chest.2018.08.232 Abstract PURPOSE: The use of intravenous vitamin C for sepsis is increasing. Vitamin C interferes with point-of-care (POC) glucose monitoring devices that use the glucose-dehydrogenase method of testing (e.g. Accu-Chek, Roche, Indianapolis, IN). Spuriously elevated POC glucose levels have been reported in patients with burns after large [...]

Authors: Marik PE PMID: 29684467 DOI: 10.1016/j.pharmthera.2018.04.007 Abstract Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans, however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant and an enzyme cofactor for many important biological reactions. Sepsis results in the overwhelming production of reactive oxygen species with [...]

Authors: Schwalfenberg GK. PMID: PMC5494092 DOI: 10.1155/2017/6254836 Abstract Objective: To review the evidence for the use of vitamin K supplementation in clinical conditions such as osteoporosis, vascular calcification, arthritis, cancer, renal calculi, diabetes, and warfarin therapy. Quality of evidence: PubMed was searched for articles on vitamin K (K1 and K2) along with books and conference [...]

Auhtors: Schwalfenberg GK PMID: 28698808 PMCID: PMC5494092 DOI: 10.1155/2017/6254836 Abstract Objective: To review the evidence for the use of vitamin K supplementation in clinical conditions such as osteoporosis, vascular calcification, arthritis, cancer, renal calculi, diabetes, and warfarin therapy. Quality of evidence: PubMed was searched for articles on vitamin K (K1 and K2) along with books [...]

Authors: Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J PMID: 27940189 DOI: 10.1016/j.chest.2016.11.036 Abstract Background: The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. Methods: In this retrospective before-after clinical study, we compared the outcome and clinical course of [...]

Authors: Zhang P, Tsuchiya K, Kinoshita T, Kushiyama H, Suidasari S, Hatakeyama M. PMID: 27733681 PMCID: PMC5114405 DOI: 10.1074/jbc.M116.743815 Abstract Vitamin B6 includes six water-soluble vitamers: pyridoxal (PL), pyridoxamine (PM), pyridoxine (PN), and their phosphorylated forms. Pyridoxal 5'-phosphate (PLP) is an important cofactor for many metabolic enzymes. Several lines of evidence demonstrate that blood levels [...]

Authors: Al-Jassim KB, Jawad AA, Al-Masoudi EA, Majeed SK Abstract The objective of this study was to assess the effects of repeated administration of ivermectin alone or with the combination of Vitamin C on kidney function and histopathological effects on kidney and lung of rabbits. Total of 48 mature female rabbits were used in this [...]

Auhtors: Nimptsch K, Rohrmann S, Kaaks R, Linseisen J PMID: 20335553 DOI: 10.3945/ajcn.2009.28691 Abstract Background: Anticarcinogenic activities of vitamin K have been observed in animal and cell studies. Objective: On the basis of the growth inhibitory effects of vitamin K as observed in a variety of cancer cell lines, we hypothesized that dietary intake of [...]