Authors: Hiedra R, Lo KB, Elbashabsheh M, Gul F, Wright RM PMID: 32662690 PMCID: PMC7441798 DOI: 10.1080/14787210.2020.1794819 Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has affected almost 2.5 million people worldwide with almost 170,000 deaths reported to date. So far, there is scarce evidence for the current treatment options available for COVID-19. Vitamin C [...]

Authors: Fontana F, Cazzato S, Giovanella S, Ballestri M, Leonelli M, Mori G PMID: 32838081 PMCID: PMC7363608 DOI: 10.1016/j.ekir.2020.07.008 Abstract Kidney dysfunction is frequently reported in patients with coronavirus disease 2019 (COVID-19). A recent large cohort study described an incidence of acute kidney injury (AKI) of 36% in patients who were hospitalized with COVID-19; AKI [...]

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an emergent global threat which is straining worldwide healthcare capacity. As of May 27th, the disease caused by SARS-CoV-2 (COVID-19) has resulted in more than 340,000 deaths worldwide, with 100,000 deaths in the US alone. It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19. Ascorbic acid is a crucial vitamin necessary for the correct functioning of the immune system. It plays a role in stress response and has shown promising results when administered to the critically ill. Quercetin is a well-known flavonoid whose antiviral properties have been investigated in numerous studies. There is evidence that vitamin C and quercetin co-administration exerts a synergistic antiviral action due to overlapping antiviral and immunomodulatory properties and the capacity of ascorbate to recycle quercetin, increasing its efficacy. Safe, cheap interventions which have a sound biological rationale should be prioritized for experimental use in the current context of a global health pandemic. We present the current evidence for the use of vitamin C and quercetin both for prophylaxis in high-risk populations and for the treatment of COVID-19 patients as an adjunct to promising pharmacological agents such as Remdesivir or convalescent plasma.

Authors: dos Santos LM. DOI: 10.30574/gscbps.2020.11.3.0155 Abstract COVID-19 has become an international pandemic and is causing a worldwide public health emergency; therefore, an effective treatment is urgently needed. The hypothesis is that Covid virus interferes with the cobalamin metabolism, causing symptoms of cobalamin deficiency. This is plausible to infer, because there are symptoms of vitamin [...]

Authors: Fatima S, Zaidi SS, Alsharidah AS, Alijaser FS, Banu N. PMID:PMC7295866 DOI: 10.1136/bmjnph-2020-000085 Abstract The immune system protects the host from pathogenic organisms (bacteria, viruses, fungi, parasites). To deal with this array of threats, the immune system has evolved to include a myriad of specialised cell types, communicating molecules and functional responses. The immune [...]

Auhtors: Duan F, Mei C, Yang L, Zheng J, Lu H, Xia Y, et al. PMID: 32382009 PMCID: PMC7206016 DOI: 10.1038/s41598-020-64880-x Abstract Vitamin K2 has been shown to exert remarkable anticancer activity. However, the detailed mechanism remains unclear. Here, our study was the first to show that Vitamin K2 significantly promoted the glycolysis in bladder [...]

Authors: Boretti A, Banik BK PMID: 32322486 PMCID: PMC7172861 DOI: 10.1016/j.phanu.2020.100190 Abstract The recent outbreak of Covid19 has required urgent treatments for numerous patients. No suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of WHO therapies of choice, that are two antivirals developed for other pathologies, is controversial. Therefore, alternative approaches [...]

Authors: Cheng RZ PMID: 32328576 PMCID: PMC7167497 DOI: 10.1016/j.medidd.2020.100028 Abstract The COVID-19 (SARS-2-Cov) pandemic, first reported in Wuhan, China, is now spreading to many continents and countries, causing a severe public health burden. Currently, there is no vaccine or specific antiviral drug for this deadly disease. A quick, deployable and accessible, effective and safe treatment [...]

Authors: Moskowitz A, Donnino MW PMID: 32148929 PMCID: PMC7024754 DOI: 10.21037/jtd.2019.12.82 Abstract Thiamine (vitamin B1) is a water-soluble vitamin essential for human health. Thiamine deficiency is causal and/or contributory in a number of debilitating diseases including beri-beri, the Wernicke-Korsakoff syndrome, optic neuropathy, and others. While thiamine deficiency is relatively rare in developed nations as a [...]

Authors: Colunga Biancatelli RM, Berrill M, Marik PE PMID: 31852327 DOI: 10.1080/14787210.2020.1706483 Abstract There is a growing interest in the administration of vitamin C beyond the treatment of hypovitaminosis C in malnourished patients. This has been driven by a 2016 ‘before-after’ study which suggested a substantial survival benefit from a protocol that included hydrocortisone, ascorbic [...]