• Published On: December 5, 2019

    Reference: Both UFH and NAH alleviate shedding of endothelial glycocalyx and coagulopathy in LPS-induced sepsis.

    Authors: Huang X, Han S, Liu x, Wang T, Xu H PMID: 32010252 PMCID: PMC6966138 DOI: 10.3892/etm.2019.8285 Abstract Sepsis commonly progresses to disseminated intravascular coagulation and induces the activation of heparanase (HPA) and the shedding of endothelial glycocalyx constituents, including syndecan-1 (SDC-1) and heparan sulphate (HS). However, the degradation of glycocalyx and its association with [...]

  • Published On: August 7, 2014

    Reference: Nitazoxanide: A first-in-class broad-spectrum antiviral agent.

    Authors: Rossignol JF PMID: 25108173 PMCID: PMC7113776 DOI: 10.1016/j.antiviral.2014.07.014 Abstract Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the treatment of influenza. A Phase 2b/3 clinical trial recently published in The Lancet Infectious Diseases found that oral administration of nitazoxanide [...]