Authors: Hadanny A, Abbott S, Suzin G, Bechor Y, Efrati S PMID: 30269074 PMCID: PMC6169752 DOI: 10.1136/bmjopen-2018-023387 Abstract Objectives: The aim of the study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) in participants suffering from chronic neurological deficits due to traumatic brain injury (TBI) of all severities in [...]

Authors: Mutz J, Edgcumbe DR, Brunoni AR, Fu CH PMID: 29763711 DOI: 10.1016/j.neubiorev.2018.05.015 Abstract We examined the efficacy and acceptability of non-invasive brain stimulation in adult unipolar and bipolar depression. Randomised sham-controlled trials of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and theta-burst stimulation (TBS), without co-initiation of another treatment, were included. We [...]

Authors: Liu S, Sheng J, Li B, Zhang X doi: https://doi.org/10.3389/fnhum.2017.00526 Abstract Non-invasive brain stimulation (NBS) is a promising treatment for major depressive disorder (MDD), which is an affective processing disorder involving abnormal emotional processing. Many studies have shown that repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) over the prefrontal cortex [...]

Authors: Dunlop K, Hanlon CA, Downar J PMID: 26849183 PMCID: PMC5434820 DOI: 10.1111/nyas.12985 Abstract Major depressive disorder (MDD) and substance use disorders (SUDs) are prevalent, disabling, and challenging illnesses for which new treatment options are needed, particularly in comorbid cases. Neuroimaging studies of the functional architecture of the brain suggest common neural substrates underlying MDD [...]

Auhtors: Meidenbauer JJ, Mukherjee P, Seyfried TN Abstract Background Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain [...]

Auhtors: Seyfried TN, Kiebish MA, Marsh J, Shelton LM, Huysentruyt LC, Mukherjee P PMID: 20804725 DOI: 10.1016/j.bbabio.2010.08.009 Abstract Malignant brain tumors are a significant health problem in children and adults. Conventional therapeutic approaches have been largely unsuccessful in providing long-term management. As primarily a metabolic disease, malignant brain cancer can be managed through changes in [...]

Auhtors: Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN PMID: 18703489 PMCID: PMC2582368 DOI: 10.1194/jlr.M800319-JLR200 Abstract Otto Warburg first proposed that cancer originated from irreversible injury to mitochondrial respiration, but the structural basis for this injury has remained elusive. Cardiolipin (CL) is a complex phospholipid found almost exclusively in the inner mitochondrial membrane [...]

Auhtors: McGirt MJ, Chaichana KL, Gathinji M, Attenello F, Than K, Ruiz AJ, Olivi A PMID: 18797358 DOI: 10.1227/01.NEU.0000315282.61035.48 Abstract Objective: Patients with malignant brain astrocytomas are at high risk for developing hyperglycemia secondary to frequent corticosteroid administration. Several clinical studies have shown that hyperglycemia is associated with poor outcome in multiple disease states. Furthermore, [...]

Auhtors: Zhou W, Mukherjee P, Kiebish MA, Markis WT, Mantis JG, Seyfried TN PMID: 17313687 PMCID: PMC1819381 DOI: 10.1186/1743-7075-4-5 Abstract Background: Malignant brain cancer persists as a major disease of morbidity and mortality in adults and is the second leading cause of cancer death in children. Many current therapies for malignant brain tumors fail to [...]

Auhtors: Li L, Connelly MC, Wetmore C, Curran T, Morgan JI PMID: 12782575 Abstract Cancer cells escape from growth control by accumulating genetic and epigenetic alterations. In rare instances, epigenetic changes alone are oncogenic. Furthermore, agents that modify DNA methylation or chromatin structure can restore a normal phenotype to cells harboring oncogenic mutations. However, it [...]