Authors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]

Authors: Chowdhury AT, Shahbaz M, Karim MR, Islam J, Dan G DOI: 10.14744/ejmo.2021.16263 Abstract Objectives: We investigated the outcomes of Ivermectin-Doxycycline vs. Hydroxychloroquine-Azithromycin combination therapy in mild to moderate COVID19 patients. Methods: Patients were divided randomly into two groups: Ivermectin 200µgm/kg single dose + Doxycycline 100mg BID for ten days in group A, and Hydroxychloroquine [...]

Authors: Tripathy S, Dassarma B, Roy S, Chabalala H, Matsabisa MG PMID: 32450198 PMCID: PMC7243790 DOI: 10.1016/j.ijantimicag.2020.106028 Abstract Chloroquine (CQ) and its analogue hydroxychloroquine (HCQ) have long been used worldwide as frontline drugs for the treatment and prophylaxis of human malaria. Since the first reported cases in Wuhan, China, in late December 2019, humans have [...]

Auhtors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]

Authors: de Moreuil C, Alavi Z, Pasquier E PMID: 31633823 PMCID: PMC6983516 DOI: 10.1111/bcp.14131 Abstract Recurrent miscarriage (RM) and vasculoplacental disorders, such as preeclampsia (PE), affect women of childbearing age worldwide. Vascular endothelial dysfunction and immunological impairment are associated with both RM and PE. To date, there is no effective or optimal therapeutic approach for [...]

Authors: Shukla AM, Shukla AW PMID: 31844421 PMCID: PMC6905642 DOI: 10.7573/dic.2019-9-1 Abstract Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney [...]

Authors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 doi: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]

Auhtors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 DOI: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]

Authors: Plantone D, Koudriavtseva T PMID: 29737455 DOI: 10.1007/s40261-018-0656-y Abstract The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), [...]

Auhtors: Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC, Fuchs CS PMID: 24821822 PMCID: PMC4041680 DOI: 10.1634/theoncologist.2014-0086 Abstract Background: Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients [...]