Auhtors: Oberoi S, Robinson PD, Cataudella D, Culos-Reed SN, Davis H, Duong N, et al.
PMID: 29458789 DOI: 10.1016/j.critrevonc.2017.12.011
Abstract
Purpose: Objective was to determine whether physical activity reduces the severity of fatigue in patients with cancer or hematopoietic stem cell transplant (HSCT) recipients.
Methods: We conducted a meta-analysis of randomized trials comparing physical activity with control interventions for the management of fatigue in patients with cancer or HSCT recipients.
Results: There were 170 trials included. Physical activity reduced the severity of fatigue when compared to all control groups (standardized mean difference -0.49, 95% confidence interval -0.60 to -0.37; P < 0.00001). Aerobic, neuromotor, resistance and combination exercises were all effective in reducing fatigue although smaller effects were observed with resistance exercises (P interaction = 0.01). Other intervention and patient characteristics did not influence the effect of physical activity on the severity of fatigue.
Conclusions: Physical activity was effective at reducing fatigue in patients with cancer and HSCT recipients across patient sub-groups. Determining the best approaches for safe implementation should be a priority.
Keywords: Cancer; Exercise; Fatigue; Meta-analysis; Physical activity; Randomized trial.
Source: https://pubmed.ncbi.nlm.nih.gov/29458789/
Archive: https://archive.is/AE9mF
