Auhtors: Mahatme MS, Bargade MB, Hiware SK, Motlag MM
doi: https://doi.org/10.4103/jpp.jpp_8_21
Abstract
Objectives: To compare the effects of atorvastatin and rosuvastatin in type II diabetes mellitus (T2DM) patients with dyslipidemia. Materialsand Methods: Eighty patients with history of T2DM of more than 3 months duration, glycated hemoglobin <7%, dyslipidemia, and normalelectrocardiogram were included in the randomized double-blind trial. The patients received either tablet atorvastatin 20 mg or rosuvastatin10 mg once a day along with metformin and glimepiride twice daily orally. Patients were evaluated by the change in estimated averageglucose (eAG), lipid profile, and incidence of adverse drug reactions (ADRs). Results: Rise in fasting blood sugar (FBS), postprandial bloodsugar, and eAG were significant in the atorvastatin group as compared to the rosuvastatin group where there was a significant increase only inFBS levels. Changes in lipid parameters and incidence of ADR were similar in both the groups. Conclusion: Rosuvastatin can be preferredto atorvastatin in T2DM with dyslipidemia due to less variation in the blood sugar parameters, effective control over lipid profile, pleiotropiceffects, and less microsomal interactions
Keywords: Diabetes dyslipidemia, microsomal interactions of statin, pleiotropic effects of statins, statin in diabetes
