[SFMedic]

Such an Amazing Paper. I have been wondering about this for Decades. As a Special Forces Medic back in the 1970’s we were trained to recognize fever patterns for various disease states to help in diagnosis of diseases with limited diagnostic instrumentation. And over time I noticed the decline of this knowledge and the decreasing routine temperatures in individuals. No one could provide a logical answer for this trend. Finally this amazing paper has brought Light to this very subject.

Dr. Wunderlich’s publication can be found here. https://archive.org/details/ontemperatureind00wunduoft/page/n15/mode/2up

Thanks Again For Your Research

David Paul

[IMA-HelenT]

So interesting given your experience as a Special Forces Medic and the changes you’ve observed over the decades.

Interesting to hear that declining routine body temperatures were something you had noticed long before seeing this research.

Thank you also for sharing Dr. Wunderlich’s publication. We will pass your comments and the link along to Matthew Cormier, I’m sure he’ll be very interested to read your perspective.

[jwemd]

It’s all about obesity – slows metabolism and therefore temperature, and it leads to chronic inflammation and disease. Estimated 70-80% of our population now overweight and 40% obese.

[IMA-HelenT]

That’s an interesting point.

The paper does explore the relationship between declining body temperature, metabolic function and chronic inflammation, so metabolic health is certainly part of the picture.

However, Matthew Cormier’s review suggests the trend may be more complex than obesity alone, looking at a number of possible contributing factors including metabolic dysfunction, chronic infections, changes to the microbiome and environmental exposures.

It’s a fascinating area and clearly one where there is still a lot to understand. Thanks for adding this perspective to the discussion.

[Wolfgang May]

We constantly live in heated rooms. Temperature stimuli that trigger Thermogenesis are missing!

Cold stimulus, cold training stimulates thermogenesis in muscles and brown fat cells. Brown adipose tissue is directly regulated by the sympathetic nervous system (primarily via norepinephrine) and thyroid hormones.

Uncoupling protein-1 (PGC-1α) ensures that heat is generated instead of adenosine triphosphate (ATP), the usual product of cellular respiration through oxidative phosphorylation.

At low ambient temperatures and low blood glucose concentrations (fasting), more brown adipose tissue was activated, while less was activated in individuals with a smoking history, older age, and higher Body Mass Index (BMI).

Wang, W., Seale, P. Control of brown and beige fat development. Nat Rev Mol Cell Biol 17, 691–702 (2016). https://doi.org/10.1038/nrm.2016.96

Cold training activates the regulator PGC-1α, which stimulates mitochondrial biogenesis and respiration in muscle cells, enhances fat oxidation in brown adipose tissue, and leads to the conversion of white adipose tissue into beige adipose tissue, which participates in thermogenesis.

Cold exposure, moderate endurance exercise, fasting, or massage therapy lead to an increase in PGC-1α in human skeletal muscle.

Alterations in PGC-1α function have been observed in, among other conditions, type 2 diabetes, cardiovascular, and neurodegenerative diseases. In these diseases, reduced PGC-1α function leads to impaired mitochondrial function and energy homeostasis.

Lin et al., Metabolic control through the PGC-1 family of transcription coactivators, Cell Metab. 2005

Scarpulla et al.: Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network, Biochim Biophys Acta. 2011; uniprot.org – PPARGC1A,

Sergio Rius-Pérez¹ et al.: PGC-1 α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism

Oxid Med Cell Longev. 2020 Mar 9:2020:1452696. doi: 10.1155/2020/1452696.eCollection 2020.