Hi Jooya,
I used MetabolicWise (thanks to Peara for posting that as I’d not prev heard of it but now will use!) and got this response: “Severe neuroinvasive disease (less than 1%): In a small minority—most commonly older adults or individuals with underlying immune or metabolic vulnerability—the virus can cross into the central nervous system, causing encephalitis (brain inflammation), meningitis, or acute flaccid paralysis . Supporting baseline mitochondrial and immune health helps reinforce the blood-brain barrier and the brain’s specialized defense systems against severe viral neuroinvasion.”
What I am learning is we need to protect the mitochondria at all costs, in all diseases, not just WNV. Two things I recommend to most patients are methylene blue (assuming one is G6PD-negative) which is a mitochondrial antioxidant (rare, the only 5 I am aware of are MB, melatonin and vitamin D [indirectly], CoQ10 and glutathione) and now urolithin A, which as a mitochondrial rejuvenator, increases mitophagy (a subtype of autophagy, best viewed as the body’s version of a dump truck).
Other things that I have not researched enough but may be helpful to your friend include low-dose naltrexone, DMSO, and chlorine dioxide. All seem to be Swiss-army type things, helpful in many different conditions.
Agree with Peara, they need to find a functional/integrative/Lifestyle Med type physician who is more open to trying different things, not the standard pharmaceuticals. Hope this helps!