[jeb77]

I wasn’t familiar so I had to look up ‘thrombocythemia’ and JAK2V617F … [had a nice conversation with ChatGPT].

Correct Understanding:

• The JAK2V617F mutation occurs first, causing a dysregulated JAK-STAT signaling pathway.
• This leads to overproduction of blood cells, including platelets, which results in essential thrombocythemia (ET).
• The mutation predisposes an individual to develop ET, polycythemia vera (PV), or primary myelofibrosis (PMF), depending on other genetic and biological factors.

Key Mechanism:

1. Mutation in JAK2 gene (JAK2V617F) →
2. Constant activation of JAK-STAT pathway (growth signal always “on”) →
3. Increased platelet production by megakaryocytes →
4. Essential thrombocythemia (high platelet count) develops

Does Thrombocythemia Cause JAK2V617F?

No, having high platelet counts does not trigger the JAK2V617F mutation. The mutation is a somatic (acquired) genetic change that occurs in a single hematopoietic stem cell, which then expands abnormally.

If the above is correct — then your question is whether the ‘shots’ triggered the JAK2V617F mutation … which then resulted in thrombocythemia [ET]. According to ChatGPT — VERS didn’t have too many reports from the mRNA shots [21 cases] … but I’m not so sure VERS is a reliable source. I’d be suspicious of the shots causing this too. ☼ How soon from the shots did you figure out you ET ..??… [You said it was mild … so that’s a good thing at least]

[Stephanie W]

Hello,

I had 2 Moderna vaccines in 2021. My platelets started to increase in 2021 and this year they’re moderately high.I went for an investigation and I was tested JAK2 +.

I have no symptons. My followup is next week. I’m in the midst of seeing how I can lower the platelets and decreasing the spike protein.