[IMA-GregT]

That’s a great question sc380.

If anyone has experience and or an helpful answer, please do post it by reply.

[IMA-HelenT]

Hi @sc380 Here are a few links that may be helpful about NAC

Dr. Saleeby and Scott Marsland, FNP-C, talk about augmented NAC and how Scott uses it to treat patients suffering from long COVID and long vax.

https://imahealth.org/courses/whole-body-health-with-dr-saleeby/lessons/whole-body-health-4/

8 Reasons to love NAC

https://imahealth.org/8-reasons-to-love-n-acetyl-cysteine-nac/

The links from the IMA website when using NAC to search

https://imahealth.org/search/?q=NAC+

[sc380]

Ty Helen! Saleeby Video super helpful:)

[IMA-HelenT]

Delighted it was helpful. Keep us posted

[Jeff Gerber]

Hi @sc380 , I’m giving Augmented NAC a try right now per the Dr. Tina Peers protocol of 600mg per day. I ramped up for a few days (200mg 2 days, 400mg 2 days) and then on May 7th, 2025, I started taking 600mg per day with an activated charcoal in the afternoon, and I still am taking Augmented NAC to date. June 30th I am having my spike protein antibodies retested, so that will be close to the 2 month mark of 600mg a day.

For reference, April 7th, 2025, my spike protein antibodies were 10,177 and were likely still close to that when I began Augmented NAC exactly 1 month later. On February 28th, 2024 they were >25,000.

A note about taking NAC that I learned from another YouTube video is that NAC works best when not in the presence of protein. So, try to take it 30 minutes prior to a meal.

I will be closely testing every month or so to give a good resolution chart of the impact from Augmented NAC. I’m very happy to share what I learn with everyone here and personally will be interested in visualizing the chart in Excel.

Dr. Peers mentioned that there is some urine test that is capable of testing the spike protein metabolites and that it is a way to identify if you are flushing out spike protein, though I have yet to find what that test is and if it is available to the general public.

I have no idea what rate one should expect to see antibodies decrease once the spike protein is essentially eliminated. I just asked copilot what the rate of decrease would be under normal circumstances:

“The rate at which spike protein antibodies decline varies widely depending on factors like the type of exposure (infection vs. vaccination), age, severity of illness, and individual immune response. That said, here’s a general picture:

– **After natural infection**, spike-specific IgG antibodies typically peak within a few weeks and then begin to decline over several months. Some studies suggest a half-life of around 100–120 days, though this can vary.

– **After vaccination**, especially with mRNA vaccines, antibody levels also peak within a few weeks post-dose and then gradually wane. A Canadian cohort study found that individuals with hybrid immunity (infection plus vaccination) had more durable and broader antibody responses than those with infection alone.

– **Repeated boosting** with the same spike protein sequence may lead to diminishing breadth of response over time, potentially reducing effectiveness against variants.

So while antibodies do decline, memory B cells and T cells often persist longer, contributing to ongoing immune protection even after antibody levels drop. If you’re thinking about immunity longevity or booster timing, I can help you dig deeper into that too.”

[Jeff Gerber]

One more thing, the thing that gave me near immediate relief was the nicotine protocol (look up Dr. Marco Leitzke if you’re not familiar with this). Nicotine was absolutely a miracle for me after suffering now for a couple of years. In my opinion and experience, Dr. Marco’s theory is reality. If you have spike protein jammed in your nicotinic acetylcholine receptors, nicotine clears it out. There is no risk of addiction and it’s absolutely worth trying to see if it works for you.

Sadly, the world would have been able to jump on this nicotine patch concept had the folks in Spain been listened to in April of 2020: https://theconversation.com/parches-de-nicotina-contra-la-covid-19-137287

theconversation.com

¿Parches de nicotina contra la COVID-19?

Esta sustancia podría detener la tormenta de citoquinas que ataca el cuerpo de algunos pacientes infectados por coronavirus.

[IMA-HelenT]

Thank you @jrgerber – both really helpful replies.

[sc380]

The Augmented NAC & Charcoal appear to be working for you, as evidenced from your decrease in spike Protein. I am waiting on my Augmented NAC to arrive. I am also going to try 600/mg daily.

Any side effects from NAC? Are you on Ivermectin?

Ty for tips on taking NAC and the timing involved.

[Jeff Gerber]

The drop from >25,000 to 10,177 wasn’t attributed to Augmented NAC and I only just started taking it. Unfortunately, those of us with a number of >25,000 don’t know what the actual number is, and we can’t therefore get an accurate chart of progress. We have to throw out the >25,000 number. It’s a wonderful sign the first time you have a test that shows a number below 25,000 because now you can actually tell what the impact is for what you’re doing to rid yourself of spike protein. Antioxidants, Resveratrol and red-light therapy (which produces melatonin) were my primary approaches over the past year. I also tried gamma-glutamylcysteine (a.k.a. Glyteine) which revs up the body’s glutathione instantly; however, I am now wary of that approach as I started getting more severe symptoms after a couple of weeks of daily dosing, and I don’t understand why. I wasn’t able to use intermittent fasting as an approach due to highly unusual blood sugar control issues. I’d otherwise have been doing intermittent fasting.

Ivermectin: Yes, I did do a 2-week round of Ivermectin at the same time as nicotine patches. What I’ve read is that ivermectin acts on nicotinic acetylcholine receptors. What I suspect is that ivermectin revs up that system and that is why it makes you feel better. However, it probably doesn’t clear out the spike protein from those receptors like nicotine can do. This might be why people tend to stay on ivermectin, because when they stop, the problem persists of the jammed spike protein in those receptors, and they feel bad again. With the nicotine I didn’t have to stay using the patch, I did 3.5mg for 3 days, 7mg for 7 days, then 3.5mg for 3 days and stopped… and the multitude of symptoms have all gone away and stayed away. Now my goal is riding my body of spike protein so that the receptors don’t become jammed again from circulating spike protein.

One problem we don’t know for certain is, the mRNA design was to hijack our body’s cells and trick them into producing spike protein. The question then is, “How long does this hijacking stick around for?” The most logical approach to this is to clean up cells in our body (get rid of hijacked cells) and this is where intermittent fasting likely makes the most impact.

Side effects: At first, I had loose stool, but my body adjusted to NAC within a day or two.

[sc380]

Very interesting! Ty for the feedback! I did see on Saleeby/Marsland video that Augmented NAC DOES cross the blood brain barrier, while Ivermectin DOES NOT!

I will share all of this with my functional medicine dr. I also do intermittent fasting!

[Jeff Gerber]

You’re on the mark in having a concern for crossing the blood brain barrier. There was a talk in 2023 by Dr. Cole where he discussed the mRNA design and his observations of seeing spike protein in just about every cell in the body, including the brain. He commented about seeing it in the adrenal glands and that it would be difficult to clean that up. I found that a curious point and I think this is the reasoning for why some cells are harder to clean up (I asked copilot):

“That’s exactly right—*apoptosis* is like the body’s built-in recycling program, helping eliminate cells that are damaged, no longer needed, or potentially dangerous, all in an orderly, non-inflammatory fashion.

As for your question—yes, certain cells are indeed more readily cleared than others, depending on a few key factors:

### Factors That Influence How Easily Cells Are “Cleaned Up”

1. **Cell Type and Function**

– *Short-lived cells* like neutrophils (a type of white blood cell) undergo apoptosis quickly and are rapidly phagocytosed (engulfed) by macrophages.

– *Long-lived or specialized cells* like neurons or cardiac muscle cells are more protected from apoptosis under normal conditions because they’re not easily replaced. When they do die, clearance can be trickier and sometimes more damaging.

2. **Tissue Environment**

– In immune-privileged areas like the brain or eyes, debris clearance is slower and more tightly regulated to avoid triggering inflammation.

– In contrast, tissues with high turnover like the gut lining or skin are equipped for rapid cleanup.

3. **Expression of “Eat Me” Signals**

– Apoptotic cells expose molecules like phosphatidylserine on their surface, which act as a signal to macrophages: “Come get me.”

– If these signals are weak or masked (which can happen in some diseases), cells may linger and provoke inflammation or autoimmunity.

4. **Presence of Macrophages**

– If local phagocytes are overwhelmed or dysfunctional (as in aging or chronic inflammation), cleanup gets bogged down.

5. **Pathological Interference**

– Some viruses and cancer cells actively block the apoptotic process or the cleanup signals to evade destruction.

So while apoptosis is beautifully orchestrated under healthy conditions, disruptions in either the *execution* of apoptosis or the *removal* of apoptotic cells can lead to problems like chronic inflammation, autoimmunity, or cancer.

Would you like to explore how this ties into diseases like lupus or cancer, or perhaps look at how dietary or lifestyle factors influence apoptosis?”

[IMA-GregT]

👍

[IMA-GregT]

👍

[sc380]

Super helpful information! Ty to ALL for your feedback

[Jeff Gerber]

Resveratrol timing

One more piece of information. I recently learned that resveratrol has a very important key property of inducing autophagy.

Copilot:

“Yes, resveratrol does influence the behavior of mTOR, and quite directly at that. It has been shown to **inhibit mTOR activity** by competing with ATP at its binding site. This inhibition leads to the induction of autophagy—a cellular cleanup process that’s often beneficial in contexts like cancer suppression, neuroprotection, and metabolic regulation.

Interestingly, resveratrol doesn’t just act on mTOR in isolation. It also activates **AMPK**, a cellular energy sensor that further suppresses mTOR signaling. This dual action—direct inhibition and upstream modulation—makes resveratrol a particularly intriguing compound in the context of aging, cancer, and metabolic diseases.

If you’re thinking about how this ties into broader pathways like autophagy, apoptosis, or even nutrient sensing, we can definitely dig deeper. Want to explore how this compares to something like rapamycin or how it might affect different cell types?”

So, depending on your needs, such as if you’re trying to clean up spike protein or cancer, understanding this property of resveratrol can be quite useful. For example, the timing of when you take resveratrol could contribute to how much cleanup is happening during the day. Naturally, sleeping is a time of fasting and that activates cleanup. In theory (I’m not a medical professional) you could take resveratrol before bed to enhance that period of time. Once you eat a meal, especially if it has sufficient protein, the body can switch on mTOR for purposes like building muscle (Don Layman and Dr. Attia have a youtube video that talks about this).

So, I think it’s important to be aware that if you’re using resveratrol for spike protein detox, the timing will influence what your body is doing overall during the day. If you have cancer, then perhaps trying to keep mTOR switched off for the majority of the day is a good strategy (take it early in the day perhaps)? I don’t know the answers to these questions. I take it before going to bed, but short of having a formal research paper on the topic I might be inclined to take it early in the day if I had cancer. My assumption is it is probably not good in the long run to keep mTOR switched off.