[IMA-HelenT]

A great substack from Dr. Malone reacting to headlines from the mainstream media and showing us why the President’s statements about autism are backed by science. https://www.malone.news/p/autism-what-we-know

malone.news

Autism - what we know.

Science backs up President Trump’s statements

[Jeff Gerber]

I have a theory on the mechanism of acetaminophen. When you overdose on acetaminophen, what kills you is depletion of glutathione.

If you investigate drugs that deplete glutathione levels you find Valproic Acid, which is used in labs to induce autism in the lab rats.

So, if I were to setup some trials, I’d look at everything known to deplete glutathione (and/or create oxidative stress).

(P.S. One of our favorite supplements in the arsenal, NAC, raises glutathione levels.)

Copilot:

Yes — valproic acid can lower glutathione levels, at least under certain conditions.

📌 Key findings from research:

• Acute administration of sodium valproate in animal studies significantly depleted glutathione (GSH) in both liver homogenates and mitochondrial fractions, which is important because mitochondrial GSH is a small but critical pool for protecting cells from oxidative stress.
• Human data in children with epilepsy show that valproic acid therapy is associated with lower glutathione-S-transferase (GST) activity and higher lipid peroxidation compared to healthy controls, suggesting an imbalance in antioxidant defenses.
• Chronic administration in some studies did not consistently reduce total glutathione, but oxidative stress markers remained elevated, meaning the antioxidant system was still under strain.

💡 Mechanistic note:
Valproic acid is metabolized in the liver to reactive intermediates. Detoxifying these intermediates consumes glutathione, and if the demand outpaces synthesis, depletion can occur. This is one proposed pathway for valproate-associated hepatotoxicity.

<hr>

If you’d like, Jeffrey, I can map this into a visual chart showing:

• Drug class (antiepileptic)
• Mechanism of glutathione depletion
• Acute vs. chronic effects
• Potential mitigation strategies (e.g., NAC supplementation, monitoring liver enzymes)

That would make it easier to integrate into your broader oxidative stress and toxicology framework. Would you like me to prepare that?

Prenatal exposure to valproic acid (VPA) is one of the most widely used laboratory methods to simulate certain autism‑like features in animals, especially rodents.

🧪 How the VPA model works

• Timing is critical: In mice and rats, a single dose of VPA is typically given to the pregnant dam at a specific gestational stage (often embryonic day 12.5 in mice, which corresponds to a key window in neural tube and cortical development).
• Dose: Commonly around 500–600 mg/kg sodium valproate in rodents, adjusted for species and strain.
• Mechanism:

• VPA is a histone deacetylase (HDAC) inhibitor, altering gene expression during brain development.
• It can disrupt the balance between excitatory and inhibitory neurotransmission (↑ glutamatergic, ↓ GABAergic signaling in cortex).
• It influences neural migration, synaptogenesis, and cortical layering.
• It increases oxidative stress and can deplete glutathione, adding a metabolic stress component.

[Jeff Gerber]

I suppose the conclusion here is that if you have to take acetaminophen or other such drugs (remember that it is also an additive to other pain killers such as hydrocodone) then you should probably be taking NAC in combination with it.

Of course, NAC does not have big pharma behind it, cornering the market; therefore, you’re not likely to hear that you should consider taking the two in combination.

I think a proper product would simply have a proper balance of both in one capsule, but no pharmaceutical company is going to spend the extra money to do that.

[Jeff Gerber]

Oh yes, and this is a video clip showing how one indoctrinates a new medical doctor into the Church of RCT Fundamentalism, a church backed by Big Pharma, of course: https://youtu.be/gD6olRJ8S3I

[IMA-HelenT]

Great point @jrgerber , the saddest thing I have seen even from people I know is the hate of the Trump administration makes them blind to doing any research at all. I feel like screaming from the rooftops that listening and then verifying information you get from big pharma does not make you a supporter of a political party, it makes you a responsible person and a caring parent.

Thanks for sharing your learnings with us.

The IMA we really want patients to feel empowered, to be curious and to work with their provider to take charge of their health, you set a good example of this.

[IMA-HelenT]

Senior Fellow, Dr. Liz Mumper always presents a balanced measured view backed by years of experience, watch her recent interview with the National News Desk https://www.facebook.com/share/v/1BVCgMctAW/ She discussed why she doesn’t recommend the use of acetaminophen to her patients and her views on the vaccine schedule.

facebook.com

1.1K views · 48 reactions | What’s driving the exponential rise in autism—and why listening to parents is so important. This morning, pediatrician and IMA Senior Fellow Dr. Elizabeth Mumper joined host Jan Jeffcoat on The National Desk to discuss new developments linking Tylenol to autism risk, why she hasn’t recommended it to patients in decades, the role of individual risk factors in autism, and the critical importance of listening to parents about their children’s health. Watch now. Learn more about Dr. Mumper and find her IMA Series, 'Kid's Corner with Dr. Liz,' here: https://imahealth.org/courses/kids-corner-with-dr-liz/ Find Dr. Mumper's 'Parent’s Guide to Childhood Immunizations' here: https://imahealth.org/tools-and-guides/parents-guide-to-childhood-immunizations/ Don't miss next week's webinar, 'Are 72 Vaccines Too Many? A Legal Case Against the CDC' (Wednesday, October 1 at 7pm ET). | Frontline Covid19 Critical Care Alliance

What’s driving the exponential rise in autism—and why listening to parents is so important. This morning, pediatrician and IMA Senior Fellow Dr. Elizabeth Mumper joined host Jan Jeffcoat on The...

[Paul Smith]

I’m afraid that it will be irrelevant unless RFKJr & Co. can prove the lie. There will be new childhood diseases which will take lives and mothers will line their babies up for the newest and greatest, ‘safe and effective’ injections that become available as the illness peters out, as they all do, and the total will grow to 75 or 80 or higher and the industry will have to buy new coffers as the money rolls in even as the side effects continue to mount. We seem to be pretty stupid that way.

[IMA-GregT]

Hear you loud and clear @shortstop . There was a lovely note from Jeffrey Tucker (about 8.5 mins in) though in this week’s show, “We now have the people who as experts can take on the fake experts.”

https://imahealth.org/state-of-the-movement-2025/

That’s immensely powerful stuff. It gives me the hope I need to keep seeing that it’s a light at the end of the tunnel, instead of an oncoming train.

imahealth.org

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