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Question – Japan’s self-amplifying RNA vaccine – and shedding
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Question – Japan’s self-amplifying RNA vaccine – and shedding
Hi, I’m new here, I’m going to be traveling to Japan in a few months and I just learned about the self-amplifying RNA covid vaccine they have been using as one of their booster offerings since the 2024-2025 season. As well as containing RNA encoding the spike protein it also includes RNA for other proteins including RNA polymerase that form a replicon so that more spike RNA is made inside the cell prior to the spike protein being made. I have been reading as much as I can about shedding but most of that information is a year or two old. Does anyone know if the major component of shedded vesicles is spike RNA, or is it spike protein? And can anyone offer any information on the self-amplifying vaccine in particular – does it shed more or less than the regular mRNA vaccines, and what happens if RNA polymerase (RNA or protein) is shed along with the spike RNA, I assume that’s not a good thing but how bad is it? Is there anything I can do to protect myself? I will be taking spike detox supplements for sure.
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2 Replies
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@kqualty Welcome, and just to mention your post went to spam. I’ve moved it here. I’m sure you’re going to get a bunch of great responses.
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The RNA polymerase itself is very stable once it’s made in the cell and won’t degrade in open air if it’s expelled in aerosolized form indoors. But the amount that someone would be exposed to would likely be very little from an injectable delivery given the polymerase only exists inside cells and would require cellular destruction en mass of affected tissues and subsequent release of that in a form that can be absorbed by additional host cells using a carrier….like an LNP. Which does not exist except in the gene therapy product.
Intranasal or mucosal delivery routes may make exposure higher as the incidence of aerosolized exposure becomes higher from coughing and sneezing from a treated individual just from mucosal deposition. How many in a given crowd on average would have taken the nasal vs injection is an unknowable statistic for a given sample population at that specific time in an area just because it’s so dynamic. So do they favor the nasal route or the injectable route primarily in Japan….that’s a question I don’t have an answer for.
Of course if you are in a crowded area exposure risk goes up for all cause contagions not just the ones you’re concerns are with.
Outdoors and exposed to sunlight, UV and IR light can denature many proteins both by oxidation reactions and thermal denaturing if it’s above 50C say on a dark surface. So best advice would be to avoid indoor crowded spaces but if you are indoors, then a proteolytic compound like Augmented NAC, Nattokinease, Serrapeptase and Bromelain combined with an n95 may help with the aerosolized exposure routes. But, the RNA encoding mechanism itself without a lipid nanoparticle delivery component to shuttle it into a cell has a very low likelihood of acting in the same way as the vaccine delivery would be. So, realistically your primary exposure will be the spike protein component delivered through exhalation exosomes, as that will be the highest pathogenic part you would be exposed to at any given time in an aerosolized free form since that is what the hijacked cells in a vaccinated individual will be cranking out. The self amplifying as the name implies will make more spike protein since it makes additional copies of the RNA polymerase from it’s transcription activities over conventional mRNA “therapies”.
Either way, it’s spike protein that is going to be the primary concern there overall short of coming into direct contact with body fluids of vaccinated individuals.
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