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DMSO
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DMSO
I’m looking for info on using DMSO. I just bought the roll-on type. Do I need to apply it on every problem area I have or is one site sufficient?
Thanks.
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31 Replies
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Hi
I use DMSO and just apply it on the area that is concerning me, which can be a couple – generally my neck and shoulder. Just start with the main area and small doses and build up from there. Also, check the concentration is ideal for your tolerance and make sure that your roll-on is in a glass bottle. BTW, do not allow it to drip on surfaces as it can actually damage it.-
Thank you.
Last night I had applied it to an area where I had applied a roll-on pain-relieving liquid (menthol) in the morning, and I broke out in a rash on that site.
This morning, I made sure I had washed the area before I applied the DMSO. No problems so far 2 hrs. later.
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OMG. DMSO makes anything else on the skin already, be easily absorbed, so the menthol would have been more deeply absorbed. I hope you are ok? There have been stories of toxicity of the underlying product/chemical so please be careful moving forward. Definitely WASH the skin first and leave it bare (no creams etc) before you apply DMSO.
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Thank you. Yes, I seem to be OK.
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I just found out that anyone using blood pressure meds should use caution. I have decided not to chance using DMSO. Oh well.
Thanks for your help.
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Hi, I recommend that your read the articles posted by the MWD (Midwestern Doctor):
https://substack.com/@amidwesterndoctor.
The author gives exhaustive detailed procedures about all sorts of diseases and conditions.
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Thank you. Just what I was looking for. I had the email but must have deleted it by mistake.
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A good resource and I listened to the audio version of the book by Amandha Vollmer called Healing with DMSO, packed with information, and she has been interviewed over the years, so I am sure you could find these.
Let us know how you get on please.
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In one of AMD’s articles, he gives fairly detailed instructions for how to use DMSO for after you, or a family member, believe you have had a stroke. Because of my family medical history and because I have an above average risk for stroke (and refusing to take potent prescribed blood thinners, only taking daily high-dose nattokinase, 4000 FU, x2 daily), I bought a BPA-free plastic bottle, roll-on (from the DMSO Store), of 100% DMSO a year ago; the bottle hasn’t disintegrated; so I guess it is still good for use if needed.
I told my wife to roll it on both sides of my throat (over my carotid arteries) and on my temples, if I ever collapsed with an apparent stroke, and then to immediately call the ambulance and tell the medics about my use of the DMSO. AMD said that would probably save me from the dire complications of a stroke, if that simple treatment were done without delay.
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I use it and just apply where it’s needed. sometimes I also put it on other spots. Don’t put it over tattoos. It pushes them deeper
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Thank you. I know I need to be cautious but never know what’s going to be a problem. I appreciate your help.
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DMSO is a solvent, so it will take anything on your skin, hands, etc. and move it into your body. Sometimes, that’s what you want, but you don’t want eg. dyes from your clothing, to be absorbed. I make sure to apply DMSO to a clean, dry surface; if I’m adding another oil or ?, put it on immediately; then let it dry completely before getting dressed. My physio warned me about this a decade ago.
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Thank you.
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Here is an article about ivermectin’s effect on the nervous system and brain – in susceptible individuals or in unusual formulations – that might make a person think twice before using DMSO simultaneously with it.
Yilmaz, S., B. Göktaş, İ. Ateş, and M. Çelik. 2026. “Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management.” Journal of Applied Toxicology46, no. 6: 1856–1870. https://doi.org/10.1002/jat.70166.
https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jat.70166
After reading portions of this paper, I tentatively conclude that taking ivermectin at the same time as using DMSO, either topically or orally, would be too risky, because DMSO’s extraordinary solvent properties could overly expose the neurological system, including brain, via “pharmacological modulation of transporter activity,” to ivermectin. The simultaneous presence of DMSO (even though there’s some evidence that alone it has positive effects on the brain, https://medimush.co.uk/a/blog/post/dmso-and-brain-health-research) could conceivably constitute or simulate an atypical formulation of ivermectin, or the equivalence of a supratherapeutic dosing or a prolonged exposure pattern, substantially increasing ivermectin’s toxic risk.
Selected excerpts from this paper:
“Collectively, evidence from both human and animal studies demonstrates that ivermectin possesses a wide therapeutic margin under controlled conditions, yet exhibits a clinically meaningful potential for neurotoxicity and systemic toxicity under specific circumstances. Early controlled human trials established that ivermectin is generally well tolerated at doses substantially exceeding approved therapeutic levels in healthy adults, with minimal neurological adverse effects observed under regulated clinical settings. However, post-marketing surveillance, pharmacovigilance analyses, and detailed case reports have unequivocally shown that serious neurotoxicity can occur, even at standard therapeutic doses, in susceptible individuals.
A central and unifying finding across human and animal literature is the critical protective role of BBB integrity and transporter-mediated efflux, particularly via the ATP-binding cassette transporter ABCB1, historically referred to as MDR1, which encodes the efflux protein P-glycoprotein. Although the terms ABCB1, MDR1, and P-glycoprotein are often used interchangeably, ABCB1 denotes the gene, MDR1 represents its classical pharmacogenetic designation, and P-glycoprotein refers to the functional transmembrane transporter expressed on endothelial cells of the BBB. Under physiological conditions, P-glycoprotein actively transports ivermectin from the luminal membrane of brain capillary endothelial cells back into the systemic circulation, thereby limiting passive diffusion across tight junction–sealed paracellular pathways and maintaining low CNS exposure.
Experimental knockout models, pharmacological inhibition studies, and naturally occurring loss-of-function mutations consistently demonstrate that disruption or saturation of ABCB1/P-glycoprotein–mediated efflux markedly increases brain penetration of ivermectin, resulting in prolonged activation of GABAergic and glutamate-gated chloride channels and subsequent neurological toxicity.
This mechanistic cascade provides a coherent explanation for the discrepancy between the favorable safety profile observed in controlled trials and the occurrence of severe neurotoxic events in genetically susceptible individuals or during pharmacological modulation of transporter activity.
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Taken together, integrated human and animal data indicate that ivermectin neurotoxicity arises primarily from altered pharmacokinetic exposure rather than intrinsic loss of safety at therapeutic dosing. Across species, variability in ABCB1/P-glycoprotein–mediated efflux, developmental maturity of the BBB, and pharmacological modulation of transporter activity collectively determine the degree of CNS penetration.
Clinical reports during the COVID-19 pandemic further emphasize that atypical formulations, supratherapeutic dosing, and prolonged exposure patterns substantially increase toxic risk.
These observations support a unified toxicological framework in which formulation, exposure context, and individual susceptibility—rather than dose alone—govern the neurological safety profile of ivermectin.”
[MY COMMENT: DMSO’s presence would probably have an important impact of this combination of factors (formulation, exposure context, and individual susceptibility) in a way that could unfavorably affect ivermectin’s safety profile. More research on ivermectin in the presence of DMSO seems warranted.]
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I just started using DMSO internally. I use the PharmaDMSO brand from Idaho. Very pure. I use it for spike-induced inflammation and what a difference it has made! So amazing! My MD at UCD Medical was really excited when I told him I was using it to reduce inflammation (which really surprised me). He said it is excellent for inflammation, adding that it tastes terrible. It does taste terrible but the brand I buy is not quite as bad as the first brand I tried. The PharmaDMSO brand is more pure and has a little touch of lemon. I take the DMSO with unsweetened pomegranate juice and water. I take 1 teaspoon daily. It was better for me to split the dose 1/2 tsp each morning and evening, but life gets busy so now I just take all at once. Don’t put in hot coffee or tea. DMSO is inactivated above 140 degrees F.
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Thank you for the info.
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Which product did you purchase for oral consumption?
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You did not say how much DMSO you actually used per dose. Just saying 1 tsp is not enough information, because readers won’t know how much you diluted it with the pomegranate juice and water. So, was it 1 tsp of pure DMSO, which was mixed with a convenient amount of juice for taste, or were you sipping 1 tsp of the solution of DMSO?
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Update: I put in a dropper full, about 1 tsp, into my morning coffee when I feel bad back pain and small fiber neuropathy. Stuff tastes terrible but not too bad in coffee. I use pharmaceutical grade DMSO. Do not take orally if you take prescription medication. I am not on any rx meds. There is a book on Amazon “The DMSO Handbook for Doctors”. I highly suggest buying it.
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Our Dr. Saleeby has also weighed in on DMSO. Lots of info in this Whole Body Health too.
imahealth.org
Whole Body Health Episode 34: All About DMSO (Dimethyl Sulfoxide)
All About DMSO (Dimethyl Sulfoxide) In this episode of ‘Whole Body Health,’ Dr. JP Saleeby discusses DMSO, what it may do for human health, the potential downsides, and how to incorporate it properly. DMSO (Dimethyl Sulfoxide) is a simple small … Continue reading
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Thank you.
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👍
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It looks like the reader would be required to “enroll” in the course and have his progress tracked. That seems like more involved than simply reading and taking notes on what he has to say on the subject.
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This is timely information. 🙂
I just loaned my Healing with DMSO book to a friend I thought might benefit from it, and she showed me the caution (page 19) of not using when on prescription drugs. I was embarrassed to not have noticed that before (although no one in my family, thankfully, is on any Rx meds) Vollmer only mentions diuretics, which makes sense. However, she is wondering if there’s a source of more information about that precaution? I didn’t see it in MWD’s postings….
Also, thank you for the link to more info and the Idaho source….Will check that out for sure. I have purchased the 70% roll-on applications from the DMSO Store. I have since then twice poured boiling water on my hand (getting clumsy as I age, I guess) and immediately applied that. The pain was gone in an instant, and the skin never even blistered. No pain or even redness after a day. Amazing stuff.
Thank you, all
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👍 Thanks for this note. Most helpful.
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I went to their website. Which specific product are you using internally?
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Good information here:
https://imahealth.org/forums/groups/public-forum/forum/discussion/dmso/ https://slope3.com
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Can you apply DMSO to your body if you are on Zoloft medication? and also could you apply it to your throat for a thyroid nodule?
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Yes. Latex, powder free.
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I wouldn’t put gloves on. Wouldn’t be sure what’s on the gloves. I apply it with clean fingers.👍
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