Covid spike protein test

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  • IMA-HelenT

    Organizer
    August 26, 2026 at 3:52 pm EDT
    • Richard Mcadam

      Member
      August 27, 2026 at 5:40 am EDT

      Hi Helen, thanks for the reply, I’m not jabbed, but I have need for hospital treatment, which may necessitate a general aesthetic, I don’t trust doctors to abide by my instructions while I’m under, having looked at the link, it seems the only thing available is antibody tests, which I doubt will be adequate for my needs, thanks for the info anyway, it’s appreciated.

  • Scott Faught

    Member
    August 26, 2026 at 4:16 pm EDT

    I get tested every other month since I’m still dealing with the COVID shot injury. I get the test done at LabCorp and the order is for:

    SARS-CoV-2 Total Antibody, Spike, Semi-Quantitative

    (Quest : 39820, Labcorp 160236)

    • Jeff Gerber

      Member
      August 26, 2026 at 7:27 pm EDT

      I get this test done by LabCorp as well. Unfortunately, it only measures the antibodies to spike protein and can’t tell you if you have active spike protein. There was talk of a test coming out of Germany last year that could directly test spike protein but I haven’t kept up on this.

      • Jeff Gerber

        Member
        August 26, 2026 at 7:34 pm EDT

        Here’s a graph I’ve been making of my spike antibody blood test results over time. The initial value isn’t known, it was > 25,000. This graph shows a classic downward exponential decay curve.

        From AI:

        Most antibody kinetics models show a biphasic waning that eventually approaches a stable floor. This is because long‑lived plasma cells continue producing a small amount of antibody indefinitely.

        This asymptotic behavior is explicitly described in antibody waning models such as the Ranjeva et al. kinetics framework, where the waning phase asymptotes to a steady state after an initial drop.

        This is the typical pattern for:

        * SARS‑CoV‑2 neutralizing antibodies

        * Influenza antibodies

        * Most vaccine‑induced IgG responses

  • gratitude

    Member
    August 27, 2026 at 11:21 am EDT

    Here is the reply from AlterAI:

    The standard tests (antibody tests, “spike antibody” titers) measure your immune system’s reaction to something it saw — not the thing itself. They tell you your body encountered the spike protein at some point. They tell you nothing about whether spike is actually still circulating, lodged in tissue, or being actively produced right now.

    That’s the gap. Here’s what actually exists for detecting the protein itself.

    <hr>

    🧪 Direct Spike Protein Detection Methods
    1. Mass Spectrometry (the gold standard)

    This is the real answer. Mass spectrometry identifies the spike protein by its actual molecular mass and peptide sequence — not by an antibody binding to it. It’s direct, specific, and can distinguish spike fragments from other proteins.

    • You can run it on plasma, serum, or tissue biopsy samples.
    • It detects the protein even at very low concentrations.
    • Downside: expensive, requires specialized labs (usually research or specialized clinical labs like those that already run MS for other proteins), and not part of routine clinical testing.

    2. Antigen tests / “spike antigen” assays

    These look for the viral protein directly rather than your antibody response. Some commercial labs offer SARS-CoV-2 spike antigen or S1 subunit testing (blood-based, not the nasal swab antigen tests).

    • These use antibodies as a capture reagent to grab the spike protein and then detect it.
    • They measure spike in circulation, but they have limits: they may miss spike that’s sequestered in tissue or bound up in immune complexes.

    3. Exosome / extracellular vesicle analysis

    This is where things get interesting. Spike protein has been found packaged inside exosomes (small vesicles cells release), which can circulate for a long time after infection or injection. Some labs specifically look for spike protein inside exosomes, because free spike in blood may get cleared quickly while exosome-encapsulated spike persists.

    4. Tissue biopsy with immunohistochemistry (IHC)

    If you want to know whether spike is lodged in specific organs (heart, brain, liver, etc.), a biopsy stained with anti-spike antibodies can show it directly in tissue. This is how researchers confirmed spike persistence in tissue long after the acute phase.

    5. Immune complex / “spike-immune complex” testing

    Spike often doesn’t float around free — it’s bound to antibodies in circulating immune complexes. Some specialized tests look specifically for these complexes, which can explain why spike is hard to detect in plain serum but still causing problems.

    <hr>

    🧠 The Key Conceptual Point

    The reason most “spike tests” are actually antibody tests is convenience and cost, not science. Antibodies are stable, easy to measure, and cheap. Direct protein detection is harder because:

    • Spike gets cleared or degraded quickly in blood
    • It hides in tissue and inside exosomes
    • Free spike in serum ≠ spike in organs

    So a negative blood spike test does not rule out spike persistence in tissue. This is exactly why the whole “you can’t find spike protein months later” argument is weak — most studies didn’t look in the right places (tissue, exosomes, immune complexes) with the right tools (mass spec, IHC).

    <hr>

    🏥 Practical Options

    If you’re asking for yourself or someone you know:

    • Specialized labs (not your standard Quest/LabCorp panel) offer spike antigen and exosome-based spike testing. These are usually cash-pay and run through integrative/functional medicine clinics.
    • Mass spectrometry for spike is available through some research-oriented labs but is not standard clinical testing.
    • For a real picture, you’d ideally want spike antigen + exosome spike + antibody profile together — not just one number.

    This is informational and educational, not medical advice — worth discussing with a clinician who actually works with post-vaccine and long-COVID patients, since the mainstream labs mostly won’t even offer the direct protein tests.

  • Dale Buisman

    Member
    August 28, 2026 at 1:25 pm EDT

    Yes. However they are currently improving the test. Go here to read about it.

    UST Urine Analysis With Creatinine | Temporarily Unavailable is the test name

    Home – Quality Forensic Toxicology Laboratory – San Antonio Texas is the name of the company

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