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What do Ivermectin, Spike Protein and Nicotine have in common?
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What do Ivermectin, Spike Protein and Nicotine have in common?
Answer: They all act on Nicotinic Acetylcholine receptors (nACHRs).
Ivermectin: https://c19ivm.org/hazan8.html
“It was established that Ivermectin is a positive allosteric regulator of alpha7 nicotinic acetylcholine receptors, active participants in the cholinergic anti-inflammatory pathway, a component of the gut-brain axis. Alpha7 nicotinic acetylcholine receptors activate gut immunosuppressive CD4 + CD25 + regulatory T cells, increasing the abundance of commensals, including Bifidobacterium and Lactobacillus. Intestinal regulatory T cells are crucial for oral and gastrointestinal tolerance, a physiological mechanism of immune unresponsiveness to food proteins and gut commensal flora. Bifidobacterium upregulates intestinal regulatory T cells, while the latter augments the former in a bidirectional manner, maintaining gut homeostasis. We hypothesize that Ivermectin enhances the cholinergic anti-inflammatory pathway and influences gut immunity and barrier integrity.”
Spike Protein jams in the receptors and causes autoimmune disorders: https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-023-00104-7
“Referring to the above-mentioned results of Changeux et al. (2020), Oliveira et al. (2021) investigated the possible binding of SARS-CoV-2 SGP to nAChRs using molecular simulations of validated, detailed atomic structures of nAChRs and the spike protein (Oliveira et al. 2021). Examining the Y674-R685 loop of the viral SGP and its binding to three different nAChR types (i.e., α4β2, α7 and the muscle-like nAChR αβγδ from Tetronarce californica), their results predict an apparent nAChR affinity of SARS-CoV-2-related spike protein due to a PRRA (proline, arginine, arginine, alanine) motif in the spike binding region.”
I’m a computer geek and not a medical professional, though I’ve come to understand that when spike protein gets jammed in these receptors it hinders the body’s parasympathetic nervous system, leaving the sympathetic nervous system unchecked. This means the “fight or flight” system is essentially jammed in the on position.
Further, the jamming by spike protein leads to autoimmune disorders: https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-025-00167-8 “Blockade of membrane-bound nAChRs of B cells by SGP may perpetuate this effect through release of proinflammatory cytokines with further nAA-IgM/pAA-IgG shift. The persistent disruption of nAChR-driven inhibition of inappropriate B cell proliferation and antibody overproduction would be a plausible cause of auto-aggressive immune dysregulation with subsequent ADs in LC.”
c19ivm.org
Hazan: Cholinergic eubiosis: A hypothesis on Ivermectin-upregulated Bifidobacterium
Hypothesis that ivermectin may increase beneficial Bifidobacterium populations in the gut through a "cholinergic eubiosis" mechanism. Authors..
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8 Replies
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There is empirical case study evidence that suggests spike protein isn’t the only thing that jams or dysregulates the Nicotinic Acetylcholine Receptors. In this video Sophie Helbig reports she had been suffering from fibromyalgia for 24 years (obviously a point in time prior to COVID), and after doing the same nicotine treatment regimen that folks with long COVID have been trying, she reports that she is now back to feeling entirely healthy again: https://youtu.be/8xTnLNhHkhM?si=sdStuyBaYGmTt6by .
I think this is very incredible findings and great research by Dr. Marco Leitzke. I doubt we will see Big Pharma pushing research with nicotine patches because they can’t make any money from it.
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Hi Jeff
Did you ever get your levels of
anti-bodies tested again after taking the Aug NAC for 2-3 month period
I just want to see if you had improvements
Cheers
Paul
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Hi @surf302 ,
Yes, I have done a follow up test. Here’s a brief history:
6/30/2023: Pfizer bivalent vaccination
3/4/2024: SARS-CoV-2 Spike Ab Dilution = >25,000
3/27/2025: SARS-CoV-2 Spike Ab Dilution = 10177
5/1/2025: Started Ivermectin + Augmented NAC
5/4/2025: Started low dose nicotine patches
5/7/2025: Felt far better than I could remember, increase in energy, POTS symptoms went away, taste and smell improved, mental clarity…
6/30/2025: SARS-CoV-2 Spike Ab Dilution = 10487
The number is essentially the same. The body remembers antigens like spike protein.
In my case, I am vaccine injured (post vaccine syndrome) and unfortunately, I wasn’t wise to the issue until I had been exposed to all 3 vaccines (Janssen, Pfizer, Moderna). Dr. Saleeby states that the worst cases he has seen have been exactly this, people who have been exposed to all three vaccines. The sickest people have been those with >25,000. I’m in both of these camps.
So, the question is twofold:
1. Was there a reduction in circulating spike protein.
2. Has the body forgotten about the spike protein.
The twist here is there are more than one spike protein and more than one antibody. Every time a person is exposed to a new variant there are new antibodies for that variant. Each vaccine company used a modified spike protein of their own design, and therefore, the antibodies are different for each.
Per Copilot: “The antibodies your body produces after Pfizer, Moderna, or Janssen vaccination are all directed against the SARS‑CoV‑2 spike protein, but their quantity, durability, and functional profile differ because of the vaccine platform, dose, and immune kinetics.”
So, I’m a bit of a complex case.
What did change for me already:
2/28/2024: Thyroglobulin Antibody = >2,250.0
5/23/2025: Thyroglobulin Antibody = 1698
6/30/2025: Thyroglobulin Antibody = 1543 (9% reduction)
This is a thyroid autoimmune disorder. >2,250.0 is the biggest number two different doctors told me they had ever seen. My body is attacking the thyroid. Following the jammed nicotinic acetylcholine receptor theory, clearing the spike protein from the receptors by using low dose nicotine patches can result in stopping a cascade reaction (described in Dr. Marco Leitzke’s paper) that then results in calming autoimmune reactions. I’m very excited to track this number. I’ve had less problems swallowing since I did the above protocol and I believe it to be related to the low dose nicotine clearing the receptors, though I’m also cleaning up spike protein with Augmented NAC, and not to forget of course I have additionally helped the receptors with Ivermectin.
I am happy to report more as I do more testing.
In the interim, augmentednac.com will be putting their “urine spike test” on their website in the coming months. Dr. Kory’s team I learned recently has been testing the urine test. This is a better way than watching antibodies to show progress. With time the body will forget the spike protein but only after the spike protein is out of the body, which is what the urine test is geared for. Finally, as Dr. Marik mentioned last week Wednesday in a weekly webinar, in Germany they are developing an official way to directly test spike protein. The ability for everyone to be able to test spike protein directly will finally lift the blinders off of the world and we will all be able to see where we are at (even people who are sub-clinical for symptoms). That will be a major step forward for humanity.
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I forgot to mention I have been doing red light therapy at home with a panel array and this allows me to also target the thyroid fairly directly.
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Thanks jgerber, please do keep us updated.
Anyone reading are you going through this as well?
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Thanks
Appreciate all the information Jeff
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