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What do Ivermectin, Spike Protein and Nicotine have in common?
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What do Ivermectin, Spike Protein and Nicotine have in common?
Answer: They all act on Nicotinic Acetylcholine receptors (nACHRs).
Ivermectin: https://c19ivm.org/hazan8.html
“It was established that Ivermectin is a positive allosteric regulator of alpha7 nicotinic acetylcholine receptors, active participants in the cholinergic anti-inflammatory pathway, a component of the gut-brain axis. Alpha7 nicotinic acetylcholine receptors activate gut immunosuppressive CD4 + CD25 + regulatory T cells, increasing the abundance of commensals, including Bifidobacterium and Lactobacillus. Intestinal regulatory T cells are crucial for oral and gastrointestinal tolerance, a physiological mechanism of immune unresponsiveness to food proteins and gut commensal flora. Bifidobacterium upregulates intestinal regulatory T cells, while the latter augments the former in a bidirectional manner, maintaining gut homeostasis. We hypothesize that Ivermectin enhances the cholinergic anti-inflammatory pathway and influences gut immunity and barrier integrity.”
Spike Protein jams in the receptors and causes autoimmune disorders: https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-023-00104-7
“Referring to the above-mentioned results of Changeux et al. (2020), Oliveira et al. (2021) investigated the possible binding of SARS-CoV-2 SGP to nAChRs using molecular simulations of validated, detailed atomic structures of nAChRs and the spike protein (Oliveira et al. 2021). Examining the Y674-R685 loop of the viral SGP and its binding to three different nAChR types (i.e., α4β2, α7 and the muscle-like nAChR αβγδ from Tetronarce californica), their results predict an apparent nAChR affinity of SARS-CoV-2-related spike protein due to a PRRA (proline, arginine, arginine, alanine) motif in the spike binding region.”
I’m a computer geek and not a medical professional, though I’ve come to understand that when spike protein gets jammed in these receptors it hinders the body’s parasympathetic nervous system, leaving the sympathetic nervous system unchecked. This means the “fight or flight” system is essentially jammed in the on position.
Further, the jamming by spike protein leads to autoimmune disorders: https://bioelecmed.biomedcentral.com/articles/10.1186/s42234-025-00167-8 “Blockade of membrane-bound nAChRs of B cells by SGP may perpetuate this effect through release of proinflammatory cytokines with further nAA-IgM/pAA-IgG shift. The persistent disruption of nAChR-driven inhibition of inappropriate B cell proliferation and antibody overproduction would be a plausible cause of auto-aggressive immune dysregulation with subsequent ADs in LC.”
c19ivm.org
Hazan: Cholinergic eubiosis: A hypothesis on Ivermectin-upregulated Bifidobacterium
Hypothesis that ivermectin may increase beneficial Bifidobacterium populations in the gut through a "cholinergic eubiosis" mechanism. Authors..
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2 Replies
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There is empirical case study evidence that suggests spike protein isn’t the only thing that jams or dysregulates the Nicotinic Acetylcholine Receptors. In this video Sophie Helbig reports she had been suffering from fibromyalgia for 24 years (obviously a point in time prior to COVID), and after doing the same nicotine treatment regimen that folks with long COVID have been trying, she reports that she is now back to feeling entirely healthy again: https://youtu.be/8xTnLNhHkhM?si=sdStuyBaYGmTt6by .
I think this is very incredible findings and great research by Dr. Marco Leitzke. I doubt we will see Big Pharma pushing research with nicotine patches because they can’t make any money from it.
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